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首页> 外文期刊>Frontiers in neuroendocrinology >Mom doesn't care: When increased brain CRF system activity leads to maternal neglect in rodents
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Mom doesn't care: When increased brain CRF system activity leads to maternal neglect in rodents

机译：妈妈不在乎：当大脑CRF系统活动增加时，啮齿动物的孕产妇忽视

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摘要

Mothers are the primary caregivers in mammals, ensuring their offspring's survival. This strongly depends on the adequate expression of maternal behavior, which is the result of a concerted action of "pro-maternal" versus "anti-maternal" neuromodulators such as the oxytocin and corticotropin-releasing factor (CRF) systems, respectively. When essential peripartum adaptations fail, the CRF system has negative physiological, emotional and behavioral consequences for both mother and offspring often resulting in maternal neglect. Here, we provide an elaborate and unprecedented review on the implications of the CRF system in the maternal brain. Studies in rodents have advanced our understanding of the specific roles of brain regions such as the limbic bed nucleus of the stria terminalis, medial preoptic area and lateral septum even in a CRF receptor subtype-specific manner. Furthermore, we discuss potential interactions of the CRF system with other neurotransmitters like oxytocin and noradrenaline, and present valuable translational aspects of the recent research.
机译：母亲是哺乳动物的主要看护人，确保他们的后代的生存。这强烈依赖于母体行为的充分表达，这是“亲母体”与“抗母体”神经调节剂如催产素和皮质素释放因子（CRF）系统的齐节作用的结果。当基本的Peripartum适应失败时，CRF系统对母亲和后代的负面生理，情感和行为后果常常导致产妇忽视。在这里，我们对CRF系统在母体大脑中的影响提供了详细和前所未有的审查。啮齿动物的研究已经了解了脑区的特定作用，例如静脉底核，内侧静脉区域和外侧隔膜的肢体床核，即使以CRF受体亚型特异性方式也是如此。此外，我们讨论CRF系统与其他神经递质如催产素和去甲肾上腺素等神经递质的潜在相互作用，并提出了最近研究的有价值的平移方面。

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