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首页> 外文期刊>Frontiers in neuroendocrinology >The hypothalamic-pituitary-adrenal axis as a substrate for stress resilience: Interactions with the circadian clock
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The hypothalamic-pituitary-adrenal axis as a substrate for stress resilience: Interactions with the circadian clock

机译：下丘脑 - 垂体 - 肾上腺轴作为应力弹性的基材：与昼夜钟的相互作用

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Stress, primarily processed via the hypothalamic-pituitary-adrenal (HPA) axis, engages biological pathways throughout the brain and body which promote adaptation and survival to changing environmental demands. Adaptation to environmental challenges is compromised when these pathways are no longer functioning optimally. The physiological and behavioral mechanisms through which HPA axis function influences stress adaptation and resilience are not fully elucidated. Our understanding of stress biology and disease must take into account the complex interactions between the endocrine system, neural circuits, and behavioral coping strategies. In addition, further consideration must be taken concerning influences of other aspects of physiology, including the circadian clock which is critical for regulation of daily changes in HPA activity. While adding a layer of complexity, it also offers targets for intervention. Understanding the role of HPA function in mediating these diverse biological responses will lead to important insights about how to bolster successful stress adaptation and promote stress resilience.
机译：胁迫，主要通过下丘脑 - 垂体 - 肾上腺（HPA）轴加工，在整个大脑和身体中接合生物途径，这促进适应和生存以改变环境需求。当这些途径不再能够最佳地运作时，适应环境挑战的适应受到损害。 HPA轴功能影响应力适应和弹性的生理和行为机制并不完全阐明。我们对压力生物学和疾病的理解必须考虑内分泌系统，神经电路和行为应对策略之间的复杂相互作用。此外，必须进一步考虑生理的其他方面的影响，包括昼夜时钟，这对于监管HPA活动的日常变化至关重要。在添加一层复杂性时，它还提供干预的目标。了解HPA功能在调解这些不同的生物反应中的作用将导致关于如何抵御成功应力适应和促进压力弹性的重要见解。

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