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首页> 外文期刊>Frontiers in neuroendocrinology >Neuroendocrine pathways underlying risk and resilience to PTSD in women
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Neuroendocrine pathways underlying risk and resilience to PTSD in women

机译:神经内分泌途径潜在的风险和适应应投入治疗的妇女

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摘要

Women are twice as likely than men to suffer from posttraumatic stress disorder (PTSD). While women have increased exposure to traumatic events of many types and have greater prevalence of comorbid psychiatric disorders compared to men, these differences do not account for the overall sex difference in the prevalence of PTSD. The current review summarizes significant findings that implicate the role of estradiol, progesterone, and allopregnanolone in female risk for PTSD symptoms and dysregulation of fear psychophysiology that is cardinal to PTSD. We also discuss how these steroid hormones influence the stress axis and neural substrates critical for the regulation of fear responses. Understanding the role of ovarian steroid hormones in risk and resilience for trauma-related adverse mental health outcomes across the lifespan in women has important translational, clinical, and intergenerational implications for mitigating the consequences of trauma exposure.
机译:妇女的可能性是男性的两倍,患有暴风肠癌应激障碍(PTSD)。 虽然女性与男性相比,妇女增加了许多类型的创伤事件,并且对合并精神病患者的流行率更高,但这些差异不会占PTSD患病率的整体性别差异。 目前的审查总结了暗示雌二醇,孕酮和亚丙烯酸尼醇在PTSD症状和恐惧心理生理学的危险中的作用的重要发现,这是基于PTSD的恐惧心理生理学。 我们还讨论这些类固醇激素如何影响应力轴和神经基材对恐惧反应的调节至关重要。 了解卵巢类固醇激素在妇女寿命中对创伤相关的不良心理健康结果的风险和恢复力具有重要的翻译,临床和代际影响,用于缓解创伤暴露的后果。

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