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首页> 外文期刊>Gastroenterology research and practice >Correlations of Human Epithelial Growth Factor Receptor 2 Overexpression with MUC2, MUC5AC, MUC6, p53, and Clinicopathological Characteristics in Gastric Cancer Patients with Curative Resection
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Correlations of Human Epithelial Growth Factor Receptor 2 Overexpression with MUC2, MUC5AC, MUC6, p53, and Clinicopathological Characteristics in Gastric Cancer Patients with Curative Resection

机译：胃癌患者治疗切除胃癌患者MUC2，MUC5AC，MUC6，P53和临床病理特征的人性上皮生长因子受体2过表达的相关性

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Background. The purpose of this study was to evaluate the relationships between HER2 overexpression in the tumor and MUC2, MUC5AC, MUC6, and p53 status and clinicopathological characteristics of gastric cancer patients. Methods. This retrospective study included 282 consecutive patients with gastric cancer who underwent surgery at the Kosin University Gospel Hospital between April 2011 and December 2012. All tumor samples were examined for HER2 expression by immunohistochemistry (IHC) and MUC2, MUC5AC, MUC6, and p53 expression by staining. A retrospective review of the medical records was conducted to determine the correlation between the presence of HER2 overexpression and clinicopathological factors. Results. The HER2-positive rate was 18.1%. Although no association was found between HER2 expression and MUC5AC, the expression of MUC2, MUC6, and p53 was significantly correlated with HER2 positivity, respectively (P = 0.004, 0.037, 0.002). Multivariate analysis revealed that HER2 overexpression and nodal status were independent prognostic factors. Conclusions. HER2 overexpression in gastric carcinoma is an independent poor prognostic factor.
机译：背景。本研究的目的是评估肿瘤和MUC2，MUC5AC，MUC6和P53胃癌患者的P53状态和临床病理特征中HER2过表达之间的关系。方法。该回顾性研究包括282例连续胃癌患者在2011年4月和2012年12月期间接受了科素大学福音医院的手术。通过免疫组织化学（IHC）和MUC2，MUC5AC，MUC6和P53表达，对所有肿瘤样品进行检查。染色。进行了对病态的回顾性审查，以确定HER2过表达和临床病理因素的存在之间的相关性。结果。 HER2阳性率为18.1％。尽管HER2表达和MUC5Ac之间没有发现关联，但MUC2，MUC6和P53的表达分别与HER2阳性显着相关（P = 0.004,0.037,0.002）。多变量分析显示，HER2过表达和节点状况是独立的预后因素。结论。 HER2胃癌的过表达是一个独立的预后因素。

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