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首页> 外文期刊>Fungal Biology Reviews >Inside-out: from endosomes to extracellular vesicles in fungal RNA transport
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Inside-out: from endosomes to extracellular vesicles in fungal RNA transport

机译：内外：从内体到真菌RNA运输中的细胞外囊

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摘要

Membrane-coupled RNA transport is an emerging theme in fungal biology. This review focuses on the RNA cargo and mechanistic details of transport via two inter-related sets of organelles: endosomes and extracellular vesicles for intra- and intercellular RNA transfer. Simultaneous transport and translation of messenger RNAs (mRNAs) on the surface of shuttling endosomes is a conserved process pertinent to highly polarised eukaryotic cells, such as hyphae or neurons. Here we detail the endosomal mRNA transport machinery components and mRNA targets of the core RNA-binding protein Rrm4. Extracellular vesicles (EVs) are newly garnering interest as mediators of intercellular communication, especially between pathogenic fungi and their hosts. Landmark studies in plant-fungus interactions indicate EVs as a means of delivering various cargos, most notably small RNAs (sRNAs), for cross-kingdom RNA interference. Recent advances and implications of the nascent field of fungal EVs are discussed and potential links between endosomal and EV-mediated RNA transport are proposed. (C) 2020 British Mycological Society. Published by Elsevier Ltd. All rights reserved.
机译：膜偶联的RNA转运是真菌生物学的新出现主题。本综述侧重于通过两个相关的细胞器（用于内细胞和细胞间RNA转移）内体和细胞外囊泡的运输RNA货物和机械技术。在穿梭型外壳表面上的信使RNA（MRNA）的同时运输和翻译是与高偏振的真核细胞（例如菌丝或神经元）相关的保守过程。在这里，我们详细介绍了核心RNA结合蛋白RRM4的内体mRNA运输机械组分和mRNA靶标。细胞外囊泡（EVS）是新的兴趣作为细胞间通信的介面，特别是在致病性真菌和宿主之间。植物 - 真菌相互作用中的地标研究表明EVS作为递送各种尸体，最值得注意的小RNA（SRNA）的手段，用于跨王国RNA干扰。讨论了初期的初步植物对真菌EVS的进展和影响，提出了内体和EV介导的RNA转运之间的潜在环节。 （c）2020英国Mycological社会。 elsevier有限公司出版。保留所有权利。

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