• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Fungal Biology Reviews >Essential, deadly, enigmatic: Polyamine metabolism and roles in fungal cells
【24h】

Essential, deadly, enigmatic: Polyamine metabolism and roles in fungal cells

机译：必要，致命，神秘：多胺代谢和真菌细胞的作用

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Polyamines are essential metabolites found in all organisms. Intracellular polyamine levels are tightly maintained by biosynthesis, degradation, uptake and excretion processes that involve regulatory mechanisms - such as the antizyme inhibitory protein - that are conserved across the kingdoms of life, indicating that polyamine levels are critical to cell function. Nonetheless, the biochemical roles of polyamines and their involvement in numerous fundamental cellular processes including aging, cell cycle progression and growth only become apparent when polyamine homeostasis is perturbed. Thus, while polyamines are present in most cells and essential for cell growth, their biochemical functions are largely enigmatic. Studies in fungi have contributed to our basic understanding of polyamines, and might continue to bridge knowledge gaps regarding polyamine metabolism and cell function. Moreover, when considering the impact of fungi - directly or indirectly, for good or for ill - on human society, closing gaps in our understanding of poly amine functions in fungal physiology is an important goal in itself that might lead to the discovery of new targets for enhancing beneficial fungal interactions and diminishing those detrimental to crop and human health. To facilitate progress towards this prospect, here we appraise what is known about polyamine metabolism in fungi, how prevalent polyamines impact fungal physiology and metabolism, and how the levels of each poly amine are maintained in the fungal cell - thus pointing to how they might be perturbed. (C) 2018 British Mycological Society. Published by Elsevier Ltd. All rights reserved.
机译：多胺是在所有生物中发现的必需代谢产物。通过生物合成，降解，摄取和排泄过程紧密地保持细胞内多胺水平，所述生物合成，降解，摄取和排泄过程，涉及调节机制 - 例如抗zzyyme抑制蛋白 - 在寿存王国范围内保守，表明多胺水平对细胞功能至关重要。尽管如此，当多胺稳态扰动时，多胺的生化作用及其在包括老化的许多基本细胞过程中，细胞周期进展和生长的增长也是显而易见的。因此，虽然多胺存在于大多数细胞中并且对细胞生长是必不可少的，但其生化功能在很大程度上是神秘的。真菌的研究有助于我们对多胺的基本理解，并且可能继续弥合关于多胺代谢和细胞功能的知识差距。此外，在考虑真菌的影响 - 直接或间接地，对于人类社会的良好或不适，在我们对真菌生理中对多种胺功能的理解下闭合差距是本身的重要目标，可能导致了新目标的发现用于增强有益的真菌相互作用，并减少对作物和人类健康有害的影响。为了促进这一前景的进展，我们在这里评估了真菌中多胺代谢的知名，多胺的多胺影响真菌生理和新陈代谢如何以及如何在真菌细胞中维持各种聚胺的水平 - 从而指着它们的方式忐忑。 （c）2018年英国Mycological社会。 elsevier有限公司出版。保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号