• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Fungal Biology Reviews >Insights into the social life and obscure side of Scedosporium/Lomentospora species: ubiquitous, emerging and multidrug-resistant opportunistic pathogens
【24h】

Insights into the social life and obscure side of Scedosporium/Lomentospora species: ubiquitous, emerging and multidrug-resistant opportunistic pathogens

机译：洞察社会生活和模糊的巩膜/洛姆瑙孢子物种的洞察：无处不在的，新兴和多药抗性的机会性病原体

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The undeniable relevance of fungal infections caused by both yeasts and molds has considerably augmented over the last four decades, becoming a serious health public problem in hospitals worldwide. In this scenario, several fungal species have emerged as human pathogens able to cause diseases in both immucompromised and immunocompetent individuals. In this context, species belonging to the Scedosporium and Lomentospora genera are awakening global attention due to their ubiquitous distribution in human-impacted environments, multidrug-resistance profile and ability to cause severe and debilitating illnesses, which culminate in laborious and meticulous medical care, substantial treatment costs and high (and unacceptable!) morbidity and mortality rates. Together, these reasons have been stimulating the international scientific community to take a hard work in order to circumvent these undesirable situations. In this way, the researchers are trying to decipher the main physiopathological events behind the successful capacity of Scedosporium/Lomentospora species to escape from host immune attacks and to resist the available chemotherapeutic treatment options. Therefore, in an attempt to add some pieces to this puzzle, the present review compiles the main published data on taxonomy, genomic, ecology, diagnosis, epidemiology, clinical manifestations, relevant clinic epidemiological statistics/metrics, current treatment options, promising alternative therapeutic approaches, expression of virulence attributes, in vitro interaction with phagocytic and non-phagocytic cells, in vivo animal infections and host immune defenses in the Scedosporium/Lomentospora field. (C) 2018 British Mycological Society. Published by Elsevier Ltd. All rights reserved.
机译：酵母和霉菌引起的真菌感染的无可否认的相关性在过去的四十年中，在过去的四十年里大大增加，成为全世界医院的严重卫生公共问题。在这种情况下，几种真菌物种被出现为能够引起免疫产量和免疫活性的疾病的人类病原体。在这种情况下，属于Scedosporium和Lomentospora属的物种由于人类受影响的环境，多药型曲线和造成严重和衰弱疾病的能力而普遍存在的普遍存在的普遍存在，这令人难以置疑的是，造成严重和衰弱的疾病的能力，这在费力和细致的医疗保健中，大量的治疗成本和高（和不可接受的！）发病率和死亡率。在一起，这些原因一直在刺激国际科学界采取努力工作，以规避这些不受欢迎的情况。通过这种方式，研究人员正在努力破译巩膜/洛姆瑙孢菌素种类成功产能背后的主要物理病理事件，以逃离宿主免疫发作并抵抗可用的化学治疗方法。因此，为了将一些拼图添加一些拼图，本综述编译了关于分类，基因组，生态，诊断，流行病学，临床表现，相关临床流行病学统计/指标，当前治疗方案，有前途的替代治疗方法的主要公开数据，毒力归属的表达，与吞噬细胞和非吞噬细胞的体外相互作用，体内动物感染和脊柱孢菌孢子场中的宿主免疫防御。 （c）2018年英国Mycological社会。 elsevier有限公司出版。保留所有权利。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号