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Antimicrobial and Wound Treatment Aspects of Micro- and Nanoformulations of Carboxymethyl, Dialdehyde, and TEMPO-Oxidized Derivatives of Cellulose: Recent Advances

机译:羧甲基,二醛和纤维素氧化衍生物的微生物和伤口处理方面的纤维素和纤维素氧化衍生物:最近的进展

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摘要

The remedy for infected chronic wounds such as diabetic foot ulcers is more complicated particularly in the case of patients with an inefficient immune system. Also, fighting against microbial infections in the wound site by available antibiotics may not be effective because of emerging antibiotic resistance properties among pathogenic bacteria and fungi. Recently, applications of micro- and nanoformulations of biomaterials have demonstrated improved therapeutic abilities for wound dressings. In this way, carboxymethyl, dialdehyde, and 2,2,6,6-tetramethylpiperidine-1-oxyl-oxidized celluloses are common biomaterials having outstanding physicochemical and therapeutic properties compared to unmodified cellulose. Therefore, in this review, recent progress in the field of wound healing and antimicrobial activities of these derivatives are presented and discussed.
机译:受感染的慢性伤口如糖尿病足溃疡的补救措施特别复杂,特别是在患有效率低下的免疫系统的情况下。 此外,由于出现了致病菌和真菌之间的新出现抗生素抗性特性,可通过可用的抗生素对伤口部位进行微生物感染的抗击。 最近,生物材料的微型和纳米型的应用已经证明了伤口敷料的改善治疗能力。 以这种方式,羧甲基,二醛和2,2,6,6,6-四甲基哌啶-1-氧基氧化纤维素是与未修饰的纤维素相比具有突出的物理化学和治疗性的常用生物材料。 因此,在本综述中,提出并讨论了这些衍生物的伤口愈合和抗微生物活性领域的进展。

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