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首页> 外文期刊>Magnetic resonance in medicine: official journal of the Society of Magnetic Resonance in Medicine >High‐resolution dynamic oxygen‐17 MR imaging of mouse brain with golden‐ratio–based radial sampling and k‐space–weighted image reconstruction
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High‐resolution dynamic oxygen‐17 MR imaging of mouse brain with golden‐ratio–based radial sampling and k‐space–weighted image reconstruction

机译：基于金属径向采样和K空间加权图像重建的高分辨率动态氧 - 17 MR成像和金属径向抽样和K空间加权图像重建

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Purpose The current study aimed to develop a three‐dimensional (3D) dynamic oxygen‐17 ( 17 O) MR imaging method with high temporal and spatial resolution to delineate the kinetics of 17 O water uptake and washout in the brains of mice with glioblastoma (GBM). Methods A 3D imaging method with a stack‐of‐stars golden‐ratio–based radial sampling scheme was employed to acquire 17 O signal in vivo. A k‐space–weighted image reconstruction method was used to improve the temporal resolution while preserving spatial resolution. Simulation studies were performed to validate the method. Using this method, the kinetics of 17 O water uptake and washout in the brains of mice with GBM were delineated after an intravenous bolus injection of 17 O water. Results The proposed 17 O imaging method achieved an effective temporal resolution of 7.56 s with a nominal voxel size of 5.625?μL in the mouse brain at 9.4?T. Reduced uptake and prolonged washout of 17 O water were observed in tumor tissue, suggesting compromised cerebral perfusion. Conclusion This study demonstrated a promising dynamic 17 O imaging approach that can delineate 17 O water kinetics in vivo with high temporal and spatial resolution. It can also be used to image cerebral oxygen consumption rate in oxygen‐17 inhalation studies. Magn Reson Med 79:256–263, 2018. ? 2017 International Society for Magnetic Resonance in Medicine.
机译：目的，目前的研究旨在开发一种具有高时和空间分辨率的三维（3D）动态氧 - 17（17 O）MR成像方法，以描绘17℃的动力学，胶质母细胞瘤（ GBM）。方法采用具有恒星金属比基径向采样方案的3D成像方法来获取体内17°信号。用于在保持空间分辨率的同时提高时间分辨率的K空调加权图像重建方法。进行仿真研究以验证该方法。使用这种方法，在静脉注射17℃的静脉注射17℃后，将17℃的水吸收和冲洗中的动力学进行划定。结果提出的17 o成像方法实现了7.56秒的有效时间分辨率，其标称体素尺寸为5.625Ωμl，在小鼠的脑中为9.4℃。在肿瘤组织中观察到17 o水的降低和长时间的冲洗，表明脑灌注受损。结论本研究表明了一个有前途的动态17 o成像方法，可以通过高时和空间分辨率在体内描绘17 o水动力学。它还可以用于在氧气-17吸入研究中的脑氧消耗率。 Magn Reson Med 79：256-263,2018 2017年医学磁共振的国际社会。

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