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首页> 外文期刊>Expert review of neurotherapeutics >Application of advanced MRI techniques to monitor pharmacologic and rehabilitative treatment in multiple sclerosis: current status and future perspectives
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Application of advanced MRI techniques to monitor pharmacologic and rehabilitative treatment in multiple sclerosis: current status and future perspectives

机译：先进的MRI技术在多发性硬化症中监测药理学和康复治疗的应用：当前状态和未来观点

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Introduction: Advances in magnetic resonance imaging (MRI) technology and analyses are improving our understanding of the pathophysiology of multiple sclerosis (MS). Due to their ability to grade the presence of irreversible tissue loss, microstructural tissue abnormalities, metabolic changes and functional plasticity, the application of these techniques is also expanding our knowledge on the efficacy and mechanisms of action of different pharmacological and rehabilitative treatments. Areas covered: This review discusses recent findings derived from the application of advanced MRI techniques to evaluate the structural and functional substrates underlying the effects of pharmacologic and rehabilitative treatments in patients with MS. Current applications as outcome in clinical trials and observational studies, their interpretation and possible pitfalls in their use are discussed. Finally, how these techniques could evolve in the future to improve monitoring of disease progression and treatment response is examined. Expert commentary: The number of treatments currently available for MS is increasing. The application of advanced MRI techniques is providing reliable and specific measures to better understand the targets of different treatments, including neuroprotection, tissue repair, and brain plasticity. This is a fundamental progress to move toward personalized medicine and individual treatment selection.
机译：介绍：磁共振成像（MRI）技术的进步和分析正在改善我们对多发性硬化（MS）的病理生理学的理解。由于它们能够级别不可逆转组织损失的存在，微观组织异常，代谢变化和功能可塑性，这些技术的应用还在扩大了我们对不同药理学和康复治疗的效果和机制的知识。涵盖了地区：本综述讨论了最近的发现，从应用先进的MRI技术来评估了MS患者药理学和康复治疗效果的结构和功能基质。讨论了当前申请作为临床试验和观察研究的结果，讨论了他们使用中的解释和可能的缺陷。最后，这些技术如何在未来发展以改善疾病进展的监测，检查治疗反应。专家评论：MS目前可用的治疗数量正在增加。高级MRI技术的应用提供可靠和具体的措施，以更好地理解不同治疗的目标，包括神经保护，组织修复和脑可塑性。这是走向个性化医学和个人治疗选择的基本进展。

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