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首页> 外文期刊>Expert review of pharmacoeconomics & outcomes research >Adding two culture-specific 'bolt-on' dimensions on the Thai version of EQ-5D-5L: an exploratory study in patients with diabetes
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Adding two culture-specific 'bolt-on' dimensions on the Thai version of EQ-5D-5L: an exploratory study in patients with diabetes

机译：在泰国版的EQ-5D-5L上添加了两种文化特异性的“螺栓上”尺寸：糖尿病患者的探索性研究

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Background: This study explored whether addition of culture-specific bolt-on dimensions, 'interpersonal relationships (IR)' and 'activities related to bending knees (AK)' improves the relevance and validity of the EQ-5D among Thai patients with diabetes. Methods: A cross-sectional study was conducted among 200 diabetic patients. Ceiling/floor effects, known-groups validity and test-retest reliability were evaluated. Hierarchical multiple regressions was performed to evaluate the incremental value of the EQ-5D+AK+IR over the EQ-5D-5L in predicting utility measured by visual analog scale (VAS). Results: The EQ-5D+AK+IR reduced ceiling effects by 34%. For known-groups validity, women and lower educated patients reported more AK problems (p-value< 0.05); however, none of the IR dimension hypotheses were supported. Both IR and AK had the weighted kappa coefficients of 0.49, indicating good reliability. Hierarchical multiple regression found that adding AK (adjusted r(2): 0.182 vs 0.156), but not IR (adjusted r(2): 0.157 vs 0.156) significantly increased the explained variance in VAS score. Conclusion: Preliminary findings suggest that AK, but not IR, may be a useful addition to the EQ-5D questionnaire for use with Thai patients. Further studies in diverse populations are needed to examine the impacts of the proposed new dimensions and determine if these cultural adaptations are justified.
机译：背景：本研究探讨了培养特异性螺栓上的尺寸，'与弯曲膝盖（AK）相关的人际关系（IR）'和“活动”提高了泰国糖尿病患者患者EQ-5D的相关性和有效性。方法：200名糖尿病患者的横截面研究进行了剖面研究。评估天花板/楼层效果，已知群体有效性和测试 - 保持性可靠性。执行分层多元回归以评估通过视觉模拟量表（VAS）测量的预测实用程序的EQ-5D + AK + IR的增量值。结果：EQ-5D + AK + IR降低了天花板效应34％。对于已知组有效性，女性和较低的教育患者报告了更多AK问题（P值<0.05）;然而，没有支持IR维度假设。 IR和AK都有0.49的加权Kappa系数，表明可靠性良好。分层多元回归发现添加AK（调整的R（2）：0.182 Vs 0.156），但不是IR（调整的R（2）：0.157 Vs 0.156）显着增加了VAS分数的解释方差。结论：初步调查结果表明AK，但不是IR，可能是与泰国患者一起使用的EQ-5D问卷的有用补充。需要进一步研究各种群体，以检查所提出的新尺寸的影响，并确定这些文化适应是否合理。

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