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首页> 外文期刊>Marine genomics >Comparative genomic analysis of three lytic Lactococcus garvieae phages, novel phages with genome architecture linking the 936 phage species of Lactococcus lactis
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Comparative genomic analysis of three lytic Lactococcus garvieae phages, novel phages with genome architecture linking the 936 phage species of Lactococcus lactis

机译：三种裂解乳球菌GARVIEAE噬菌体噬菌体，新噬菌体与基因组结构的比较基因组分析，与乳酸乳晕936噬菌体物种

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摘要

To date, a number of bacteriophages that infect Lactococcus garvieae isolated from marine fish have been identified. However, the evolutionary insight between L. garvieae phages and other viral community have not yet been immersedly investigated. In this study, completed genomic sequence of phage PLgY-30 was obtained, a comparative analysis of three lytic phages, which have been using for phage typing and treatment of L. garvieae infecting marine fish, is conducted. The results revealed that the genomes of lytic phages specific for L. garvieae isolated from diseased marine fish share a high level of homology and almost all proteins are conserved. At genome level, no similarity was detected for either PLgY-30 or PLgY-16, while PLgW-1 shares only very limited homology (1%) with other sequences in Genbank database. In addition, the function of only 35% of ORFs in the PLgY-30 phage genomes could be predicted, demonstrating that it is novel phage. At protein level, lytic phage proteins shared a significant similarity to various proteins of global phage species isolated from dairy fermentation facilities that utilize L. lactis as a primary starter culture, called the 936 phage group. Genome organization and architecture of three lytic phages are also similar to that of the 936 phage group. To our knowledge, this is the first time lytic bacteriophages infecting L. garvieae from marine fish were characterized to genome level.
机译：迄今为止，已经确定了一些感染从海洋鱼中分离的乳酸乳晕曲霉的噬菌体。然而，L. Garvieae噬菌体和其他病毒群系之间的进化洞察力尚未被沉浸地调查。在该研究中，获得了噬菌体培养物-30的完整基因组序列，进行了三种裂解噬菌体的比较分析，该噬菌体一直使用用于感染船鱼的噬菌体键入和治疗。结果表明，从患病海洋鱼中分离的L.Garvieae的裂解噬菌体的基因组居住高水平的同源性，几乎所有蛋白质都是保守的。在基因组水平下，对于普利普通-30或普利浦普利的-16没有检测相似性，而PLGW-1仅在Genbank数据库中与其他序列非常有限（1％）。此外，可以预测仅35％的ORF的of of of o-30噬菌体基因组的功能，证明它是新颖的噬菌体。在蛋白质水平中，裂解噬菌体蛋白与从乳制品发酵设施中分离的全局噬菌体种类的各种蛋白质分享了具有显着的相似性，该乳碱发酵设施中利用L.乳酸作为主要起始培养物，称为936噬菌体组。基因组组织和三种裂解噬菌体的结构也与936噬菌体组的结构类似。据我们所知，这是第一次感染来自海洋鱼类的L.Garvieae的裂解噬菌体的特征在于基因组水平。

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  • 来源
    《Marine genomics》 |2019年第2019期|共9页
  • 作者

    Truong Dinh Hoai; Nishiki Issei; Fujiwara Atushi; Yoshida Terutoyo; Nakai Toshihiro;

  • 作者单位

    Univ Miyazaki Fac Agr Gakuen Kibanadai Nishi 1-1 Miyazaki 8892192 Japan;

    Japan Fisheries Res &

    Educ Agcy Res Ctr Bioinformat &

    Biosci Natl Res Inst Fisheries Sci Yokohama Kanagawa 2368648 Japan;

    Japan Fisheries Res &

    Educ Agcy Res Ctr Bioinformat &

    Biosci Natl Res Inst Fisheries Sci Yokohama Kanagawa 2368648 Japan;

    Univ Miyazaki Fac Agr Gakuen Kibanadai Nishi 1-1 Miyazaki 8892192 Japan;

    Hiroshima Univ Lab Fish Pathol Fac Appl Biol Sci Higashihiroshima 7398528 Japan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 遗传学;
  • 关键词

    Lyfie phages; Lactococcus garvieae; Marine fish; Genome; Analysis;

    机译：Lyfie噬菌体;乳酸乳球菌;海洋鱼类;基因组;分析;

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