Complete genome sequence of Streptomyces spongiicola HNM0071(T), a marine sponge-associated actinomycete producing staurosporine and echinomycin

Zhou Shuangqing; Xiao Ke; Huang Dongyi; Wu Wenqiang; Xu Yun; Xia Wei; Huang Xiaolong

首页> 外文期刊>Marine genomics >Complete genome sequence of Streptomyces spongiicola HNM0071(T), a marine sponge-associated actinomycete producing staurosporine and echinomycin

【24h】

Complete genome sequence of Streptomyces spongiicola HNM0071(T), a marine sponge-associated actinomycete producing staurosporine and echinomycin

机译：完整的链霉菌基因组序列Spongiicola HNM0071（T），海绵相关的放线菌网生产Staurosporine和Echinomycin

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Streptomyes spongiicola HNM0071(T) is a novel marine sponge-associated actinomycete with potential to produce antitumor agents including staurosporine and echinomycin. Here, we present the complete genome sequence of S. spongiicola HNM0071, which consists of a linear chromosome of 7,180,417 bp, 5669 protein coding genes, 18 rRNA genes, and 66 tRNA genes. Twenty-seven putative secondary metabolite biosynthetic gene clusters were found in the genome. Among them, the staurosporine and echinomycin gene clusters have been described completely. The complete genome information presented here will enable us to investigate the biosynthetic mechanism of two well-known antitumor antibiotics and to discover novel secondary metabolites with potential antitumor activities.

机译：Streptomyes Spongiicola HNM0071（T）是一种新型海绵 - 相关的放线菌网，其潜力产生包括Staurosporine和Echinomycin在内的抗肿瘤剂。在这里，我们提出了S. Spongiicola HNM0071的完整基因组序列，其由线性染色体组成7,180,417bp，5669个蛋白质编码基因，18个RRNA基因和66个TRNA基因。在基因组中发现了二十七个推定的次级代谢物生物合成基因簇。其中，已经完全描述了Staurosporine和Echinomycin基因簇。本文呈现的完整基因组信息使我们能够研究两个众所周知的抗肿瘤抗生素的生物合成机制，并探讨具有潜在抗肿瘤活性的新型次生代谢物。

著录项

来源
《Marine genomics》 |2019年第2019期|共4页
作者
Zhou Shuangqing; Xiao Ke; Huang Dongyi; Wu Wenqiang; Xu Yun; Xia Wei; Huang Xiaolong;
展开▼
作者单位

Hainan Univ Hainan Key Lab Sustainable Utilizat Trop Bioresou Haikou 570228 Hainan Peoples R China;

Hainan Univ Hainan Key Lab Sustainable Utilizat Trop Bioresou Haikou 570228 Hainan Peoples R China;

Hainan Univ Hainan Key Lab Sustainable Utilizat Trop Bioresou Haikou 570228 Hainan Peoples R China;

Hainan Univ Hainan Key Lab Sustainable Utilizat Trop Bioresou Haikou 570228 Hainan Peoples R China;

Hainan Univ Hainan Key Lab Sustainable Utilizat Trop Bioresou Haikou 570228 Hainan Peoples R China;

Hainan Univ Hainan Key Lab Sustainable Utilizat Trop Bioresou Haikou 570228 Hainan Peoples R China;

Hainan Univ Hainan Key Lab Sustainable Utilizat Trop Bioresou Haikou 570228 Hainan Peoples R China;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类遗传学;
关键词
Streptomyes spongiicola; Complete genome sequence; Staurosporine; Echinomycin;

机译：streptomyes spongiicola;完全基因组序列;Staurosporine;echinomycin;

相似文献

外文文献
中文文献
专利

1. Complete genome sequence of Streptomyces spongiicola HNM0071(T), a marine sponge-associated actinomycete producing staurosporine and echinomycin [J] . Zhou Shuangqing, Xiao Ke, Huang Dongyi, Marine genomics . 2019,第期

机译：完整的链霉菌基因组序列Spongiicola HNM0071（T），海绵相关的放线菌网生产Staurosporine和Echinomycin
2. Draft Genome Sequence of the Marine Actinomycete Streptomyces sulphureus L180, Isolated from Marine Sediment [J] . Xinqing Zhao, Xiang Geng, Chao Chen, Journal of bacteriology . 2012,第16期

机译：从海洋沉积物中分离出的海洋放线菌硫脲链霉菌L180的基因组序列草案。
3. Draft Genome Sequence of the Anti-Algal Marine Actinomycete Streptomyces sp. JS01 [J] . Huajun Zhang, Su Zhang, Yun Peng, Genome Announcements . 2014,第6期

机译：草拟基因组序列的抗藻海洋放线菌链霉菌种。 JS01
4. Characterization of cytotoxic compound from marine sediment derived new actinomycete Streptomyces coelicolor strain SU5 [C] . Sudha. S, Masilamani Selvam. M Green Technology and Environmental Conservation (GTEC 2011), 2011 International Conference on . 2011

机译：来自海洋沉积物的新放线菌链霉菌coelicolor菌株SU5的细胞毒性化合物的表征
5. Isolation and characterization of a sponge-associated actinomycete that produces manzamines. [D] . Peraud, Olivier. 2006

机译：产生马扎明的海绵相关放线菌的分离和鉴定。
6. Analysis of the complete genome sequence of a marine-derived strain Streptomyces sp. S063 CGMCC 14582 reveals its biosynthetic potential to produce novel anti-complement agents and peptides [O] . Liang-Yu Chen, Hao-Tian Cui, Chun Su, -1

机译：海洋来源的链霉菌菌株的完整基因组序列分析。 S063 CGMCC 14582揭示了其生物合成潜力可产生新型的抗补体剂和肽
7. Peer Review #1 of "Analysis of the complete genome sequence of a marine-derived strain Streptomyces sp. S063 CGMCC 14582 reveals its biosynthetic potential to produce novel anti-complement agents and peptides (v0.1)" [O] . 2019

机译：同行评论“海洋衍生菌株STRESTOMYCES SP的完整基因组序列分析”＃1。S063 CGMCC 14582揭示了生产新型抗补体剂和肽（V0.1）的生物合成潜力。

Complete genome sequence of Streptomyces spongiicola HNM0071(T), a marine sponge-associated actinomycete producing staurosporine and echinomycin

摘要

著录项

相似文献

相关主题

期刊订阅