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Mass spectrometry-driven drug discovery for development of herbal medicine

机译：群众光谱驱动的药物发现，用于制剂的草药

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摘要

Herbal medicine (HM) has made a major contribution to the drug discovery process with regard to identifying products compounds. Currently, more attention has been focused on drug discovery from natural compounds of HM. Despite the rapid advancement of modern analytical techniques, drug discovery is still a difficult and lengthy process. Fortunately, mass spectrometry (MS) can provide us with useful structural information for drug discovery, has been recognized as a sensitive, rapid, and high-throughput technology for advancing drug discovery from HM in the post-genomic era. It is essential to develop an efficient, high-quality, high-throughput screening method integrated with an MS platform for early screening of candidate drug molecules from natural products. We have developed a new chinmedomics strategy reliant on MS that is capable of capturing the candidate molecules, facilitating their identification of novel chemical structures in the early phase; chinmedomics-guided natural product discovery based on MS may provide an effective tool that addresses challenges in early screening of effective constituents of herbs against disease. This critical review covers the use of MS with related techniques and methodologies for natural product discovery, biomarker identification, and determination of mechanisms of action. It also highlights high-throughput chinmedomics screening methods suitable for lead compound discovery illustrated by recent successes.
机译：草药（HM）对鉴定产品化合物对药物发现过程进行了重大贡献。目前，更多关注从HM的天然化合物中的药物发现。尽管现代分析技术的快速进步，但药物发现仍然是一个艰难而冗长的过程。幸运的是，质谱（MS）可以为我们提供有用的药物发现结构信息，已被认为是一种敏感，快速，高通量的技术，用于从后基因组时代从HM推进药物发现。必须开发一种高效，高质量的高通量筛选方法，该方法与MS平台集成，用于从天然产物中早期筛查候选药物分子。我们在能够捕获候选分子的MS上开发了一种新的Chinedomomics策略，促进他们在早期阶段的新化学结构的鉴定;基于MS的ChinyMomics引导的自然产品发现可以提供一种有效的工具，可以解决早期筛查草药免受疾病的有效成分的挑战。这项批判性综述包括使用MS与自然产品发现，生物标识识别和测定作用机制的相关技术和方法。它还突出了适用于最近成功所示的铅化合物发现的高通量下降的ChinoMics筛选方法。

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  • 来源
    《Mass Spectrometry Reviews》 |2018年第3期|共14页
  • 作者

    Zhang Aihua; Sun Hui; Wang Xijun;

  • 作者单位

    Heilongjiang Univ Chinese Med Sino Amer Chinmed Technol Collaborat Ctr Natl TCM Key Lab Serum Pharmacochem Metabol Lab Chinmed Res Ctr TCM State Adm Dept Pharmaceut Ana Heping Rd 24 Harbin 150040 Heilongjiang Peoples R China;

    Heilongjiang Univ Chinese Med Sino Amer Chinmed Technol Collaborat Ctr Natl TCM Key Lab Serum Pharmacochem Metabol Lab Chinmed Res Ctr TCM State Adm Dept Pharmaceut Ana Heping Rd 24 Harbin 150040 Heilongjiang Peoples R China;

    Heilongjiang Univ Chinese Med Sino Amer Chinmed Technol Collaborat Ctr Natl TCM Key Lab Serum Pharmacochem Metabol Lab Chinmed Res Ctr TCM State Adm Dept Pharmaceut Ana Heping Rd 24 Harbin 150040 Heilongjiang Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 质谱分析;
  • 关键词

    biomarker; chinmedomics; herbal medicine; lead compounds; mass spectrometry; metabolite; natural products;

    机译：生物标志物;ChinMedomics;草药;铅化合物;质谱;代谢物;天然产品;

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