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首页> 外文期刊>Medical care >Cost-effectiveness of Antihypertensive Medication: Exploring Race and Sex Differences Using Data From the REasons for Geographic and Racial Differences in Stroke Study
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Cost-effectiveness of Antihypertensive Medication: Exploring Race and Sex Differences Using Data From the REasons for Geographic and Racial Differences in Stroke Study

机译：抗高血压药物的成本效益：使用来自中风研究的地理和种族差异的原因，探索种族和性别差异

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Background:Antihypertensive medication decreases risk of cardiovascular disease (CVD) events in adults with hypertension. Although black adults have higher prevalence of hypertension and worse CVD outcomes compared with whites, limited attention has been given to the cost-effectiveness of antihypertensive medication for blacks.Objective:To compare the cost-effectiveness of antihypertensive medication treatment versus no-treatment in white and black adults.Research Design:We constructed a State Transition Model to assess the costs and quality-adjusted life-years (QALYs) associated with either antihypertensive medication treatment or no-treatment using data from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study and published literature. CVD events and health states considered in the model included stroke, coronary heart disease, heart failure, chronic kidney disease, and end-stage renal disease.Subjects:White and black adults with hypertension in the United States, 45 years of age and above.Measures:Yearly risk of CVD was determined using REGARDS data and published literature. Antihypertensive medication costs were determined using Medicare claims. Event and health state costs were estimated from published literature. All costs were adjusted to 2012 US dollars. Effectiveness was assessed using QALYs.Results:Antihypertensive medication treatment was cost-saving and increased QALYs compared with no-treatment for white men ($7387; 1.14 QALYs), white women ($7796; 0.89 QALYs), black men ($8400; 1.66 QALYs), and black women ($10,249; 1.79 QALYs).Conclusions:Antihypertensive medication treatment is cost-saving and increases QALYs for all groups considered in the model, particularly among black adults.
机译：背景：抗高血压药物降低了高血压的成人中心血管疾病（CVD）事件的风险。虽然黑人成年人的高血压患病率较高，但与白人相比，较差的CVD结果，已经有限的注意力对黑色抗高血压药物的成本效益。目的：比较抗高血压药物治疗的成本效益与白色无需治疗和黑人成人。搜索设计：我们建立了一个国家过渡模型，以评估与抗高血压药物治疗或无治疗相关的成本和质量调整后的生命年（qalys）使用来自中风的地理和种族差异的原因（关于）研究和出版文学。在模型中考虑的CVD事件和健康状态包括中风，冠心病，心力衰竭，慢性肾病和终末期肾病。 - 含有高血压的白色和黑人成人，45岁及以上。措施：利用关于数据和公开的文献确定CVD的年度风险。使用Medicare索赔确定抗高血压药物成本。出版文献估计了事件和健康状况费用。所有费用都调整为2012美元。使用qalys评估有效性。结果：抗高血压药物治疗是节省成本节省的，与白人无需治疗（$ 7387; 1.14 qalys），白人女性（$ 7796; 0.89 qalys），黑人男子（$ 8400; 1.66 qalys）相比，qalys增加和黑人女性（10,249美元; 1.79 qalys）。结论：抗高血压药物治疗是节省成本节省的，适用于模型中考虑的所有团体的Qalys，特别是黑人成年人。

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