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首页> 外文期刊>Mediators of inflammation >Osteopontin and Other Regulators of Angiogenesis and Fibrogenesis in the Vitreous from Patients with Proliferative Vitreoretinal Disorders
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Osteopontin and Other Regulators of Angiogenesis and Fibrogenesis in the Vitreous from Patients with Proliferative Vitreoretinal Disorders

机译：来自增殖性玻璃体障碍患者的玻璃体中血管生成和纤维发生的血管生成和纤维发生的其他调节因子

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The aim of this study was to determine the levels of the angiogenic and fibrogenic factors osteopontin (OPN), high-mobility group box-1 (HMGB1), and connective tissue growth factor (CTGF) and the antiangiogenic and antifibrogenic pigment epithelium-derived factor (PEDF) in the vitreous fluid from patients with proliferative diabetic retinopathy (PDR), proliferative vitreoretinopathy (PVR), and rhegmatogenous retinal detachment with no PVR (RD). Vitreous samples from 48 PDR, 17 PVR and 30 RD patients were studied by enzyme-linked immunosorbent assay. OPN, HMGB1, CTGF, and PEDF levels were significantly higher in PDR patients than in RD patients (P < 0.001; 0.002; <0.001; <0.001, resp.). CTGF and PEDF levels were significantly higher in PVR patients than in RD patients (P < 0.001; 0.004, resp.). Exploratory logistic regression analysis identified significant associations between PDR and high levels of HMGB1, CTGF and PEDF, between PDR with active neovascularization and high levels of CTGF and PEDF, and between PDR with traction retinal detachment and high levels of HMGB1. In patients with PDR, there were significant correlations between the levels of PEDF and the levels of OPN (r = 0.544,P = 0.001), HMGB1 (r = 0.719,P < 0.001), and CTGF (r = 0.715.P < 0.001). In patients with PVR, there were significant correlations between the levels of OPN and the levels of HMGB1 (r = 0.484,P = 0.049) and PEDF (r = 0.559,P = 0.02). Our findings suggest that OPN, HMGB1, and CTGF contribute to the pathogenesis of proliferative vitreoretinal disorders and that increased levels of PEDF may be a response to counterbalance the activity of angiogenic and fibrogenic factors in PDR and PVR.
机译：本研究的目的是确定血管生成和纤维纤维因子骨桥蛋白（OPN），高迁移率组箱-1（HMGB1）和结缔组织生长因子（CTGF）和抗血清和抗纤维素原料上皮衍生因子的水平（PEDF）在具有增殖性糖尿病视网膜病变（PDR），增殖的玻璃体病虫病（PVR）的玻璃体中的玻璃体流体，以及没有PVR（RD）的rhegmatouse视网膜脱离。通过酶联免疫吸附试验研究了48pd，17pVR和30次患者的玻璃体样本。 PDR患者OPN，HMGB1，CTGF和PEDF水平显着高于RD患者（P <0.001; 0.002; <0.001; <0.001，REAC）。 PVR患者的CTGF和PEDF水平显着高于RD患者（P <0.001; 0.004，RESP。）。探索物程回归分析确定了PDR和高水平HMGB1，CTGF和PEDF之间的显着关联，PDR与具有活性新生血管和高水平的CTGF和PEDF，以及牵引视网膜脱离和高水平的HMGB1之间的PDR。在PDR患者中，PEFF水平与OPN水平之间存在显着相关性（r = 0.544，p = 0.001），HMGB1（r = 0.719，p <0.001）和CTGF（r = 0.715.p <0.001 ）。在PVR患者中，OPN水平与HMGB1水平之间存在显着相关性（R = 0.484，P = 0.049）和PEDF（R = 0.559，P = 0.02）。我们的研究结果表明，OPN，HMGB1和CTGF有助于增殖培体障碍的发病机制，并且PEF的增加程度可能是对抗衡PDR和PVR中血管生成和纤维化因子的活性的反应。

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