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Leptospira and Inflammation

机译：Leptospira和炎症

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Leptospirosis is an important zoonosis and has a worldwide impact on public health. This paper will discuss both the role of immunogenic and pathogenic molecules during leptospirosis infection and possible new targets for immunotherapy against leptospira components. Leptospira, possess a wide variety of mechanisms that allow them to evade the host immune system and cause infection. Many molecules contribute to the ability of Leptospira to adhere, invade, and colonize. The recent sequencing of the Leptospira genome has increased our knowledge about this pathogen. Although the virulence factors, molecular targets, mechanisms of inflammation, and signaling pathways triggered by leptospiral antigens have been studied, some questions are still unanswered. Toll-like receptors (TLRs) are the primary sensors of invading pathogens. TLRs recognize conserved microbial pattern molecules and activate signaling pathways that are pivotal to innate and adaptive immune responses. Recently, a new molecular target has emerged-the Na/K-ATPase-which may contribute to inflammatory and metabolic alteration in this syndrome. Na/K-ATPase is a target for specific fatty acids of host origin and for bacterial components such as the glycolipoprotein fraction (GLP) that may lead to inflammasome activation. We propose that in addition to TLRs, Na/K-ATPase may play a role in the innate response to leptospirosis infection.
机译：钩端螺旋体病是一种重要的动物病，在全球对公共卫生的影响。本文将讨论免疫原性和致病分子在钩螺旋体感染期间的作用以及对乳骨杆菌组分免疫疗法的新靶标。 leptospira拥有各种机制，让它们避免宿主免疫系统并引起感染。许多分子有助于Leptospira粘附，侵入和殖民的能力。最近左旋螺旋状基因组的测序增加了我们对该病原体的了解。虽然已经研究了毒力因子，分子靶标，炎症的机制和由乳化血抗原引发的信号传导途径，但一些问题仍未得到答复。 Toll样受体（TLR）是入侵病原体的主要传感器。 TLRS识别保守的微生物图案分子并激活枢转的信号通路，其与先天和适应性免疫反应枢转。最近，新的分子靶标已出现 - Na / K-ATP酶 - 这可能导致该综合征中的炎症和代谢改变。 Na / K-ATPase是宿主起源的特异性脂肪酸的靶标，诸如可能导致炎症组的糖磷蛋白级分（GLP）的细菌组分。我们提出，除TLRS之外，NA / K-ATPase还可以在对腹腔镜感染的先天反应中发挥作用。

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