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Macrolide Therapy in Chronic Inflammatory Diseases

机译:慢性炎症疾病中的大环内酯治疗

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Sinobronchial syndrome is well accepted to involve the coexistence of chronic rhinosinusitis (CS) and chronic lower airway inflammation such as chronic bronchitis and diffuse panbronchiolitis (DPB). Although these diseases are resistant to several types of treatment, after discovery of the effectiveness of erythromycin on DPB, low-dose and long-term administration of macrolide antibiotics such as erythromycin, roxithromycin, and clarithromycin, are used frequently in the treatment of these diseases with remarkable success [1]. It has also reported that long-term use of azithromycin, a 16-membered macrolide antibiotic, can improve the lung functions in patients with cystic fibrosis (CF) [2]. These reports clearly indicate that the prognosis of these life-threatening airway diseases, especially DPB and CF, may improve dramatically, but the mode of action of this macrolide therapy is not fully understood. Furthermore, there is little information about the kind of diseases, which can be treated with the macrolide therapy.
机译:Sinobronchial综合征涉及涉及慢性鼻窦炎(CS)和慢性降低慢性支气管炎和弥漫性泛池炎(DPB)的慢性鼻窦炎(CS)和慢性降低呼吸道炎症的共存。虽然这些疾病对几种类型的治疗进行了抗性,但在发现红细胞的有效性后,虽然红细胞和长期施用大环内霉素,如红细胞,罗西霉素和克拉霉素,但经常用于这些疾病的治疗方法成功显着[1]。还报道,长期使用阿奇霉素,16元大环内酯抗生素,可以改善囊性纤维化患者的肺功能[2]。这些报告清楚地表明,这些危及危及危及生命的气道疾病,特别是DPB和CF的预后可能会显着改善,但这种大环内酯治疗的作用方式尚未完全理解。此外,几乎没有关于这种疾病的信息,可以用大环内德治疗治疗。

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