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首页> 外文期刊>Mediators of inflammation >High-Mobility Group Box-1 and Endothelial Cell Angiogenic Markers in the Vitreous from Patients with Proliferative Diabetic Retinopathy
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High-Mobility Group Box-1 and Endothelial Cell Angiogenic Markers in the Vitreous from Patients with Proliferative Diabetic Retinopathy

机译：来自增殖性糖尿病视网膜病变患者的高迁移率组箱-1和内皮细胞血管生成标记物

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The aim of this study was to measure the levels of high-mobility group box-1 (HMGB1) in the vitreous fluid from patients with proliferative diabetic retinopathy (PDR) and to correlate its levels with clinical disease activity and the levels of vascular endothelial growth factor (VEGE), the angiogenic cytokine granulocyte-colony-stimulating factor (G-CSF), the endothelial cell angiogenic markers soluble vascular endothelial-cadherin (sVE-cadherin), and soluble endoglin (sEng). Vitreous samples from 36 PDR and 21 nondiabetic patients were studied by enzyme-linked immunosorbent assay. HMGB1, VEGF, sVE-cadherin, and sEng levels were significantly higher in PDR patients than in nondiabetics (P = 0.008; <0.001; <0.001; 0.003, resp.). G-CSF was detected in only 3 PDR samples. In the whole study group, there was significant positive correlation between the levels of HMGB1, and sVE-cadherin (r = 0.378, P = 0.007). In PDR patients, there was significant negative correlation between the levels of sVE-cadherin and sEng (r = -0.517, P = 0.0005). Exploratory regression analysis identified significant associations between active PDR and high levels of VEGF (odds ratio = 76.4; 95% confidence interval = 6.32-923) and high levels of sEng (odds ratio = 6.01; 95% confidence interval = 1.25-29.0). Our findings suggest that HMGB1, VEGF, sVE-cadherin and sEng regulate the angiogenesis in PDR.
机译：本研究的目的是测量来自增殖糖尿病视网膜病变（PDR）患者的玻璃体流体中的高迁移率组箱-1（HMGB1）的水平，并将其水平与临床疾病活动和血管内皮生长水平相关联因子（vege），血管生成细胞因子粒细胞 - 菌落刺激因子（G-CSF），内皮细胞血管生成标记物可溶性血管内皮 - 钙粘蛋白（SVE-CDERHERIN）和可溶性腹膜（Seng）。通过酶联免疫吸附试验研究了36pdr和21例非糖尿病患者的玻璃体样本。 PDR患者的HMGB1，VEGF，SVE-CADHERIN和SENG水平显着高于非脂肪酸（P = 0.008; <0.001; <0.001; 0.003，REAC）。仅在3个PDR样品中检测到G-CSF。在整个研究组中，HMGB1和SVE-CDHERIN水平之间存在显着的正相关性（R = 0.378，P = 0.007）。在PDR患者中，SVE-CADHERIN和SENG的水平之间存在显着的负相关性（R = -0.517，P = 0.0005）。探索性回归分析确定了活性PDR和高水平VEGF之间的重要关联（差距= 76.4; 95％置信区间= 6.32-923）和高水平的Seng（差价率= 6.01; 95％置信区间= 1.25-29.0）。我们的研究结果表明，HMGB1，VEGF，SVE-CDHERIN和SENG调节PDR中的血管生成。

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