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首页> 外文期刊>Medicine and science in sports and exercise >Dermal Calcium Loss Is Not the Primary Determinant of Parathyroid Hormone Secretion during Exercise
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Dermal Calcium Loss Is Not the Primary Determinant of Parathyroid Hormone Secretion during Exercise

机译：皮肤钙损失不是运动过程中甲状旁腺激素分泌的主要决定因素

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Introduction Exercise can cause a decrease in serum ionized calcium (iCa) concentration, which stimulates parathyroid hormone (PTH) secretion and activates bone resorption. We postulated that dermal Ca loss during cycling exercise is the major determinant of the serum iCa, PTH, and bone resorption (C-terminal telopeptide of type 1 collagen [CTX]) responses. Methods To investigate this, women (n = 13) and men (n = 12) age 18 to 45 yr performed the same exercise bout under cool (18 degrees C) and warm (26 degrees C) conditions. Exercise was 60 min of cycling at similar to 75% of peak aerobic power. Sweat samples were obtained during exercise using a skin patch method, and blood samples were obtained before and during exercise and during 60 min of recovery. Results Sweat volume and estimated sweat Ca loss were 50% higher for the warm condition than the cool condition. Despite this, there were no differences between thermal conditions in the changes (mean, 95% confidence interval [95% CI]) in iCa (cool, -0.07 mg center dot dL(-1); 95% CI, -0.16 to 0.03); warm, -0.07 mg center dot dL(-1); 95% CI, -0.20 to 0.05), PTH (cool, 34.4 pg center dot mL(-1); 95% CI, 23.6-45.2; warm: 35.8 pg center dot mL(-1); 95% CI, 22.4-49.1), or CTX (cool, 0.11 ng center dot mL(-1); 95% CI, 0.08-0.13; warm, 0.15 ng center dot mL(-1); 95% CI, 0.11-0.18). Adjusting for exercise-related shifts in plasma volume revealed a marked decline in vascular iCa content in the first 15 min of exercise (cool, -0.85 mg center dot dL(-1); 95% CI, -1.01 to -0.68; warm, -0.85 mg center dot dL(-1); 95% CI, -1.05 to -0.66), before substantial sweat Ca loss had occurred. Conclusions This indicates that dermal Ca loss was not the primary trigger for the increases in PTH and CTX during exercise. Further research is necessary to understand the causes and consequences of the disruption in Ca homeostasis during exercise and specifically the extravascular shift in iCa.
机译：介绍锻炼会导致血清电离钙（ICA）浓度降低，刺激甲状旁腺激素（PTH）分泌并激活骨吸收。我们假设循环运动期间的皮肤Ca损失是血清ICA，PTH和骨吸收的主要决定因素（1型胶原蛋白[CTX]的C末端腹膜肽）的反应。研究此方法的方法，女性（n = 13）和男性（n = 12）年龄18至45岁，在冷却（18℃）和温热（26℃）条件下进行相同的运动伴侣。锻炼是60分钟的循环，类似于75％的峰值有氧功率。使用皮肤贴剂方法在运动期间获得汗液样品，并且在运动之前和期间和60分钟的回收率获得血液样品。结果汗水体积和估计的汗水Ca损失比冷静条件更高50％。尽管如此，在ICA中的变化中的热条件（平均95％置信区间[95％CI]）中没有差异（COOL，-0.07mg中心DL（-1）; 95％CI，-0.16至0.03 ）;温暖，-0.07 mg中心点DL（-1）;第95％CI，-0.20至0.05），PTH（COOL，34.4 pg中心点M1（-1）; 95％CI，23.6-45.2;温暖：35.8 pg中心点M1（-1）; 95％CI，22.4- 49.1）或CTX（冷却，0.11ng中心点M1（-1）; 95％CI，0.08-0.13;温热，0.15ng中心点M1（-1）; 95％CI，0.11-0.18）。调节血浆体积中的运动相关偏移显示在运动的前15分钟内血管ICA含量明显下降（冷却，-0.85mg中心DL（-1）; 95％CI，-1.01至-0.68;温暖， -0.85 mg中心点DL（-1）; 95％CI，-1.05至-0.66），在发生大量汗水CA损失之前。结论这表明皮肤CA损失不是运动过程中PTH和CTX增加的主要触发。进一步的研究是在运动过程中了解CASoSoTasis中断的原因和后果，特别是ICA中的血管外转移。

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