Central nervous system and other effects.

Young A

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Central nervous system and other effects.

机译：中枢神经系统等影响。

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Amylin enhanced the uptake of certain amino acids, crossed the blood-brain barrier, and increased body temperature. The physiological significance of these responses is currently unclear. An effect of peripherally injected amylin to enhance weakly trained memory fitted with similar effects of other gastrointestinal peptide hormones. Centrally administered amylin reduced locomotor and exploratory behavior. Amylin administered alone was analgesic when administered peripherally, via a non-opiate pathway. When administered in combination with opiates, there was an opiate-sparing synergy.

机译：胰岛淀粉样多肽增加了某些氨基酸的摄取，穿越了血脑屏障，并增加了体温。这些反应的生理意义目前尚不清楚。周边注射胰岛淀粉样多肽的作用是增强弱训练记忆，这种作用与其他胃肠道肽激素的作用相似。集中施用胰岛淀粉样多肽可减少运动和探索行为。当通过非阿片途径经外周给药时，单独给药的胰岛淀粉样多肽是止痛药。当与阿片类药物联合给药时，有阿片保护性的协同作用。

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《Advances in pharmacology》 |2005年第0期|共8页
作者
Young A;
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正文语种 eng
中图分类药学;
关键词
islet amyloid polypeptide; Central Nervous System; peptide hormone; Gastrointestinal; 中枢神经系统;

机译：islet amyloid polypeptide;Central Nervous System;peptide hormone;Gastrointestinal;中枢神经系统;

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Central nervous system and other effects.

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