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Skin transplantation in mice as an animal model for functional analysis of T regulatory cells

机译:小鼠皮肤移植作为T监管细胞功能分析的动物模型

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The role of T regulatory cells (Tregs) in transplantology has been widely studied over the years. The mouse model of skin transplantation is used as a quick and easy way to monitor the immune response of Tregs, vital for creation and maintenance of homeostasis and immunological tolerance. This model is extremely useful in the assessment of allograft rejection and immune tolerance induction dependent on Tregs. The procedure of skin transplantation is widely used not only in transplantology, but also in studies on the effectiveness of various immunosuppressive compounds and studies on autoimmune diseases, including diabetes, multiple sclerosis and albinism. The improved protocol of mouse tail skin grafting is easy to master, and its wide application gives many opportunities for new solutions in biomedical research.
机译:T型调节细胞(Tregs)在移植物中的作用已被广泛研究多年来。 皮肤移植的小鼠模型用作监测Tregs的免疫应答的快速简便的方法,对稳态和免疫耐受的创造和维持至关重要。 该模型在评估依赖于Tregs的同种异体移植抑制和免疫耐受诱导方面非常有用。 皮肤移植的程序不仅广泛使用,而且还广泛使用,也广泛使用了关于各种免疫抑制化合物的有效性和自身免疫疾病的研究的研究,包括糖尿病,多发性硬化和白蛋白。 鼠标尾部皮肤接枝的改进方案易于掌握,其广泛的应用为生物医学研究的新解决方案提供了许多机会。

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