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首页> 外文期刊>Medycyna Weterynaryjna >Superovulation in cattle - searching for the optimal dose, alternative routes of administration and a simplified FSH application program
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Superovulation in cattle - searching for the optimal dose, alternative routes of administration and a simplified FSH application program

机译：牛的超级化 - 寻找最佳剂量，替代管理途径和简化的FSH应用程序

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The aim of this article is to set out certain possibilities related to the simplification of the superovulation protocols (SOV) in cattle. The traditional protocols, which have been in use for decades, include as standard several injections of FSH preparations. Due to the widespread increase in the importance of the animals' welfare, alternative options for its administration are now being sought. Appropriate selection of gonadotropin as well as the dose and ratio of hormones makes it possible to limit undesirable effects such as prolonged ovarian stimulation. Adjuvants such as polyvinylpyrrolidone, polyethylene glycol, hyaluronic acid or aluminium hydroxide enable the extension of the absorption time of FSH preparations, thus reducing the amount of FSH injections. A single deposition of hormones dissolved in aqueous solutions is possible when it is administered via alternative routes, such as subcutaneous or epidural. Reduction of the amount of FSH injections may directly translate into a decrease of the stress level in animals treated by the SOV protocols and also to the improvement of the efficiency of embryo production. A significant risk factor remains the high variability of superovulation. Its effectiveness depends on a number of generally well known individual and environmental factors that should also be considered when joining SOV.
机译：本文的目标是列出了与牛中超级协议（SOV）的简化相关的某些可能性。已在几十年中使用的传统方案包括标准的FSH制剂注射。由于动物福利的重要性普遍增加，目前正在寻求其管理的替代方案。 Appropriate selection of gonadotropin as well as the dose and ratio of hormones makes it possible to limit undesirable effects such as prolonged ovarian stimulation.佐剂如聚乙烯基吡咯烷酮，聚乙二醇，透明质酸或氢氧化铝，使得FSH制剂的吸收时间延长，从而降低FSH注射量。当通过替代途径（例如皮下或硬膜外）施用时，可以单一沉积溶解在水溶液中的激素沉积。减少FSH注射量可以直接转化为SOV协议治疗的动物的应力水平的降低以及改善胚胎生产效率。显着的风险因素仍然是超级性的高度变化。其有效性取决于许多众所周知的个人和环境因素，在加入SOV时也应该考虑。

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