...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Microchemical Journal: Devoted to the Application of Microtechniques in all Branches of Science >Monitoring of warfarin therapy: Preliminary results from a longitudinal pilot study
【24h】

Monitoring of warfarin therapy: Preliminary results from a longitudinal pilot study

机译：纵向试验研究的初步结果监测：纵向试验研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

AbstractThe aim of this study was to investigate the relationship between warfarin dosage, international normalized ratio, plasma and oral fluid concentrations of warfarin, and its metabolites, namely RR/SS- and RS/SR-warfarin alcohols. Nine patients on long-term warfarin therapy (4 with stable and 5 with unstable international normalized ratio values) were longitudinally monitored for over two months by recording warfarin dosage and measuring international normalized ratio, warfarin and warfarin alcohols concentrations in oral fluid and in plasma.At equivalent dose (20–30mgweek?1), the international normalized ratio was in the range 2.0–2.5 and 1.5–3.1 for stable and unstable patients, respectively. Moreover, stable patients showed nearly double total and unbound plasma warfarin concentration, and nearly triple oral fluid warfarin concentrations compared to unstable patients. Correlations between warfarin dosage and total plasma concentration of warfarin (r=0.65,p<0.01) or RS/SR-warfarin alcohols (r=0.66,p<0.01), as well as between stimulated oral fluid and total plasma concentrations of warfarin (r=0.72,p<0.01) and RS/SR-warfarin alcohols (r=0.95,p<0.01) suggest that the relative changes of the oral fluid concentrations of these species may provide clinically useful information for monitoring individual patients. Follow-up data revealed that even in the absence of changes of warfarin dose, the oscillations of
机译：<！[cdata [ 抽象 本研究的目的是调查华法林剂量，国际归一化率，血浆和口服液浓度之间的关系华法林及其代谢产物，即RR / SS-和RS / SR-Warfarin醇。通过记录华法林剂量和测量国际标准化比例，在口腔液中和血浆中持续两个月，纵向监测了九个长期华法林治疗（具有不稳定的国际标准化比率值的5个，具有不稳定的国际标准化比率值）。 在等效剂量（20-30mgweek ？1 ），国际归一化比率分别为2.0-2.5和1.5-3.1分别用于稳定和不稳定的患者。此外，稳定的患者显示出几乎双重和未结群血浆华法林浓度，与不稳定的患者相比，几乎三倍的口服流体华法林浓度。华法林剂量与华法林总血浆浓度之间的相关性（ r = 0.65， p <0.01）或rs / sr-warfarin醇（< CE：斜体> r = 0.66， p <0.01），以及受刺激的口腔液和华法林的总血浆浓度（ r = 0.72， p <0.01）和RS / sr-warfarin醇（ r = 0.95， P <0.01）表明这些物种的口腔流体浓度的相对变化可以提供监测个体患者的临床有用的信息。随访数据表明，即使在没有华法林剂量的变化的情况下，振动

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号