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首页> 外文期刊>Microchemical Journal: Devoted to the Application of Microtechniques in all Branches of Science >A low cost method for carbamazepine, ciprofloxacin and norfloxacin determination in pharmaceutical formulations based on spot-test and smartphone images
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A low cost method for carbamazepine, ciprofloxacin and norfloxacin determination in pharmaceutical formulations based on spot-test and smartphone images

机译：基于点测验和智能手机图像的药物制剂中药物制剂中的低成本方法

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摘要

The use of digital image-based method to determine several compounds has been applied in the different fields of sciences and health area. Antibiotics and antiepileptics are used worldwide and require a strict monitoring. High cost methods using chromatographic techniques are commonly applied to the quality control of those pharmaceutical compounds. Therefore, the present study aims to present a simple and precise method to determine carbamazepine, ciprofloxacin and norfloxacin in pharmaceutical formulations using low-cost devices and digital images obtained by smartphone. Spot-tests and a box to capture the digital images were made in a 3D printer. The images were processed in the RGB system by Image J software to obtain the RGB channels signal values as analytical signal. The smartphone enabled quick and in situ analyzes, a limit of detection of 3.0, 1.0 and 1.0 mg L-1 and limit of quantification of 5.0, 3.0 and 3.0 mg L-1 were obtained for carbamazepine (CBZ), ciprofloxacin (CIP) and norfloxacin (NOR), respectively. The intra-day precision (RSD %) varied from 0.590 to 19.5 %. The developed method was compared to a method using spectrophotometry, and the results obtained by both methods were statistically equal. The proposed method allowed rapid analyzes, of about 16 s, low samples and chemical volume were required (8 mu L), and a total cost of U$ 2.00. The developed method presents a new analytical tool, environmental friendly, portable and useful for labs with limited resources.
机译：使用基于数字图像的方法来确定几种化合物已应用于不同的科学和健康区域的不同领域。在全球范围内使用抗生素和抗癫痫药，需要严格的监测。使用色谱技术的高成本方法通常适用于这些药物化合物的质量控制。因此，本研究旨在呈现一种简单且精确的方法来使用低成本装置和智能手机获得的数字图像测定药物制剂中的胭脂嗪，环丙沙星和诺氟沙星。在3D打印机中进行点测试和捕获数字图像的框。通过图像J软件在RGB系统中处理图像，以获得RGB通道信号值作为分析信号。智能手机快速且原位分析，检测限度为3.0,1.0和1.0mg L-1和5.0,3.0和3.0mg L-1的定量，用于卡巴马嗪（CBZ），Ciprofloxacin（CIP）和诺福克西辛（也不）。血液内精度（RSD％）不同于0.590至19.5％。将开发方法与使用分光光度法的方法进行比较，并且通过两种方法获得的结果均等等于。所提出的方法允许快速分析，需要约16秒，需要低样品和化学体积（8亩），总成本为2.00美元。开发方法提出了一种新的分析工具，环境友好，便携式，可用于资源有限的实验室。

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