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首页> 外文期刊>Microbial drug resistance: MDR : Mechanisms, epidemiology, and disease >Comparison of Carba NP-Direct, Carbapenem Inactivation Method, and β-CARBA Tests for Detection of Carbapenemase Production in Enterobacteriaceae
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Comparison of Carba NP-Direct, Carbapenem Inactivation Method, and β-CARBA Tests for Detection of Carbapenemase Production in Enterobacteriaceae

机译：Carba NP-Digence，Carbapenem失活法，β-Carba检测检测肠杆菌菌的检测

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摘要

Rapid and accurate detection of carbapenemase-producing isolates are extremely important for management of antimicrobial therapy and the implementation of infection control measures. We evaluated the performance of Carba NP-direct, carbapenem inactivation method (CIM), and the commercial β-CARBA tests for detection of carbapenemase production in Enterobacteriaceae . Enterobacteriaceae isolates with previously characterized carbapenemase types ( n = 110) and non-carbapenemase-producing Escherichia coli ( n = 15) isolates were tested. Sensitivities of Carba NP-direct, CIM, and β-CARBA tests were 99.0%, 92.7%, and 93.6%, respectively, while specificity was 100% for all three tests. For β-CARBA test, a 60-min incubation time instead of 30 increased the sensitivity to 98.1%, and lessened false negativity, particularly with OXA-48-like producers. Our results showed that Carba NP-direct, CIM, and β-CARBA tests are useful tools for the reliable detection of carbapenemase activity in enterobacterial isolates. Carba NP-direct is a simple, rapid, and low-cost test for routine use.
机译：快速准确地检测生产碳结构酶的分离株对于管理抗菌治疗和感染控制措施的实施非常重要。我们评估了Carba NP-Direct，Carbapenem失活方法（CIM）的性能，以及用于检测肠杆菌植物中碳癌产物的商业β-CARBA试验。测试了具有先前表征的碳结构酶类型（n = 110）和非碳结构酶产生的大肠杆菌（n = 15）分离物的肠杆菌菌的分离物。 CARBA NP-DIRGIE，CIM和β-CARBA试验的敏感性分别为99.0％，92.7％和93.6％，而所有三种测试的特异性为100％。对于β-CARBA试验，60分钟孵育时间而不是30增加敏感性至98.1％，并减少了误导性，特别是牛粪-48类似的生产商。我们的研究结果表明，CARBA NP直接，CIM和β-CARBA试验是可靠地检测肠杆菌分离株中的碳癌酶活性的有用工具。 Carba NP-Direct是一种简单，快速，低成本的常规用途测试。

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