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首页> 外文期刊>Microbial Pathogenesis >Evaluation of the safety and protection efficacy of an attenuated genotype vii newcastle disease virus strain as a candidate vaccine
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Evaluation of the safety and protection efficacy of an attenuated genotype vii newcastle disease virus strain as a candidate vaccine

机译：衰减基因型VII新城疫病毒菌株作为候选疫苗的安全性和保护疗效评估

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摘要

Newcastle disease (ND) is a serious avian infectious disease, causing severe economic loss worldwide. Its prevention depends on comprehensive vaccination scheme against Newcastle disease virus (NDV). However, current vaccine strains are of different genotypes with prevalent circulating strains (genotype VII), with significant genetic distance. Our team previously generated a genotype matched attenuated NDV strain (rmNA-1). In this study, its safety and immunization efficacy were evaluated. Its lentogenic characteristic was stable for 25 generations in embryonated chicken eggs and for six generations in SPF chickens. Overdosed administration did not cause any clinical signs or pathogenic changes in chickens. As to its immunization effect, rmNA-1 stimulated a comparable serum NDV specific antibody level to a LaSota (genotype II) strain based commercial vaccine, and provided full protection against virulent genotype VII strain challenge, with significantly reduced virus shedding period.
机译：新城疫（ND）是严重的禽类传染病，在全世界造成严重的经济损失。 其预防依赖于对新城疫病毒（NDV）的综合疫苗接种方案。 然而，目前的疫苗菌株是具有普遍循环菌株（基因型VII）的不同基因型，具有显着的遗传距离。 我们的团队以前产生了基因型匹配衰减的NDV菌株（RMNA-1）。 在本研究中，评估其安全性和免疫疗效。 其乙蛋白特性在胚胎鸡蛋中25代和SPF鸡中的六代人稳定。 过量给予给药没有引起鸡的任何临床症状或致病变化。 关于其免疫效果，RMNA-1刺激了基于溶rasota（基因型II）菌株的商业疫苗的可比较的血清NDV特异性抗体水平，并为毒性基因型VII菌株攻击提供全面保护，病毒脱落期有显着降低。

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