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首页> 外文期刊>Microbial Pathogenesis >Bioinformatics of excretory/secretory proteins of Toxoplasma gondii strain ME49
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Bioinformatics of excretory/secretory proteins of Toxoplasma gondii strain ME49

机译：弓形虫弓形虫菌株菌株菌株的生物信息学

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摘要

Toxoplasma gondii is an obligate intracellular parasite that is globally distributed and can infect almost all warmblooded animals, including humans. While vaccines are not available for prophylaxis, there are limited therapeutic options which often do not result in eradication of parasites from patients. ME49 is a cystogenic strain of T. gondii with a potential as a vaccine candidate. Excretory and secretory (ES) proteins are thought to play crucial roles in host-parasite interactions. Hence, we predicted and functionally annotated the ES proteins in T. gondii ME49 using public databases. ES proteins were further examined for the characteristics and possible functions through gene ontology (GO) term enrichment and analyses of metabolic pathways, enzyme code distribution (EC distributing) and protein domains. The potential antigenicity of T. gondii ME49 ES proteins was evaluated for the first time using Abundance of Antigenic Regions (AAR) value to predict the antigenic potential by measuring sequence length and number of antigenic regions. The results showed that the ES proteins have different AAR values at RNA and microarray level. Our studies provide valuable information for future experimental studies, including the identification of novel ES proteins of therapeutic, diagnostic and immunoprophylactic interests.
机译：Toxoplasma Gondii是全球分布的细胞内寄生虫，可以感染几乎所有的那些有动物，包括人类。疫苗不适用于预防，治疗方案有限，往往不会导致从患者中消除寄生虫。 ME49是T.Gondii的膀胱源性菌株，潜在疫苗候选者。被认为在宿主寄生虫相互作用中发挥关键作用的排泄和分泌蛋白。因此，我们预测并用公共数据库预测并在T.Gondii ME49中批注了ES蛋白。进一步检查ES蛋白，通过基因本体论（GO）富集和分析代谢途径，酶代谢分布（EC分配）和蛋白质结构域来进行特征和可能的功能。使用抗原区（AAR）值首次评价T.Gondii Me49 ES蛋白的潜在抗原性。通过测量序列长度和抗原区域的数量来预测抗原潜力。结果表明，ES蛋白在RNA和微阵列水平下具有不同的AAR值。我们的研究为未来的实验研究提供了有价值的信息，包括鉴定治疗，诊断和免疫蛋白兴趣的新型ES蛋白。

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