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首页> 外文期刊>Microbial Pathogenesis >Short communication: Uterine leptospiral infection is strongly associated to strains of serogroup Sejroe on experimentally infected hamsters
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Short communication: Uterine leptospiral infection is strongly associated to strains of serogroup Sejroe on experimentally infected hamsters

机译：短期通信：子宫乳化血管感染与实验感染的仓鼠血清群Sejroe的菌株密切相关

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摘要

Leptospira infection is influenced by the host species and the bacterial strain involved. Important differences on their tissue distribution are referred, also depending on the host and the studied strain. Considering tissue distribution of leptospires the majority of the studies focus on a single strain, or strains from the same serogroup with different inoculation doses. Nevertheless, none had associated different serogroups with their tissue distribution. Thus, the present study aims to investigate the hypothesis that tissue distribution of Leptospira spp. on experimentally infected hamsters may vary according to the strain serogroup. Females of Golden Syrian hamsters were used for the experimental infection with Leptospira isolates (n = 13) belonging to serogroups Icterohaemorrhagiae (n = 8) and Sejroe (n = 5). PCRs were conducted in renal, hepatic and uterine tissue. Seven out of the thirteen studied hamsters presented acute clinical signs and were euthanized before the 21 degrees day p.i. (strains VF237, VF52, U81, UFF-SG001, UFF-G19, UFF-B15, L1-130), while the others presented a subclinical infection. Regarding to the PCR results it was possible to observe that, all but one strain (UFF-SG001), which was detected on all the studied tissues, presented some differences on their tissue distribution. All strains could be detected on at least one tissue and a significant association was observed for the occurrence of the strains of serogroup Sejroe in uterus (p = 0.044). The results of the present study indicate that strains of serogroup Sejroe are strongly associated to uterine infection on experimentally infected hamsters.
机译：Leptospira感染受到宿主物种的影响和所涉及的细菌菌株。还提到了它们组织分布的重要差异，也取决于宿主和研究的菌株。考虑到Leptospires的组织分布，大多数研究的重点是单一菌株，或者与不同的接种剂量的相同血清组的菌株。然而，没有与其组织分布有关的不同血清组。因此，本研究旨在探讨睑杆菌SPP组织分布的假设。在实验感染的仓鼠可能根据菌株血清组而变化。金叙利亚仓鼠的女性用于乳胶血清菌（n = 13）属于血清小组（n = 8）和sejroe（n = 5）的实验感染。 PCR在肾，肝和子宫组织中进行。第十三个学习仓鼠患者呈现急性临床迹象，并在21度P.I之前被安乐死。 （菌株VF237，VF52，U81，UFF-SG001，UFF-G19，UFF-B15，L1-130），而其他人呈现了亚临床感染。关于PCR结果，可以观察到，除了所有研究的组织上检测到的所有菌株（UFF-SG001），对其组织分布呈现了一些差异。可以在至少一种组织上检测到所有菌株，并且观察到术中血群Sejroe的菌株的发生（P = 0.044）。本研究结果表明，血清群Sejroe的菌株与实验感染的仓鼠的子宫感染强烈关联。

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