• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Microbial Pathogenesis >Quorum sensing system: Target to control the spread of bacterial infections
【24h】

Quorum sensing system: Target to control the spread of bacterial infections

机译：法定传感系统：控制细菌感染的传播

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Quorum Sensing (QS) systems regulate the gene expression of different types of virulence factors in accordance with the cell population density. A literature search was performed, including electronic databases such as MEDLINE/PubMed, SciELO, and LILACS, as well as other databases not indexed, such as Google Scholar. The search was conducted between July 2018 and April 2019, through online research. Antimicrobial resistance is one of the biggest threats to global health and the dissemination of resistant microbes in the environment is a major public health problem. Therefore, it is important to develop new therapies to control the spread of resistant bacteria to humans. Thus, interference in the chemical signal (autoinducers) of the QS system has been postulated as a good alternative, technically known as "Quorum Quenching" or QS inhibitors. Inhibition of QS signaling is not intended to kill the microorganism, but to block the expression of the target genes, making the cells less virulent and more vulnerable to host immune response. Anti-virulence therapy by agents that interfere with this system in pathogenic bacteria is a well-studied strategy, including medicinal plants and their bioactive constituents, and presents good prospects. This review aims to provide an overview of the QS system in bacteria and describe the main inhibitors of the system.
机译：Quorum感测（QS）系统根据细胞群密度调节不同类型毒力因子的基因表达。执行文献搜索，包括电子数据库，如Medline / PubMed，Scielo和Lilacs，以及其他数据库未索引，例如Google Scholar。通过在线研究，搜索在2018年7月至2019年4月至2019年4月之间进行。抗菌抗性是对全球健康的最大威胁，并且环境中抗性微生物的传播是一个主要的公共卫生问题。因此，开发新的疗法是控制抗性细菌对人类的传播非常重要。因此，QS系统的化学信号（AutoInuceers）的干扰已被假定为良好的替代，技术称为“Quorum淬火”或QS抑制剂。抑制QS信号传导并非旨在杀死微生物，而是阻断靶基因的表达，使细胞不那么毒性，更容易受到宿主免疫应答的侵害。干扰该系统在致病细菌中的药剂的抗毒力治疗是一种良好研究的策略，包括药用植物及其生物活性成分，并提出了良好的前景。该审查旨在概述细菌中的QS系统，并描述系统的主要抑制剂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号