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首页> 外文期刊>Microbial Pathogenesis >Baicalin suppress growth and virulence-related factors of methicillin-resistant Staphylococcus aureus in vitro and vivo
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Baicalin suppress growth and virulence-related factors of methicillin-resistant Staphylococcus aureus in vitro and vivo

机译：黄芩苷在体外和体内抑制耐甲氧西林耐金黄色葡萄球菌的生长和毒力相关因素

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摘要

A Staphylococcus aureus (S.aureus) was isolated from pigs suffered in pneumonia that can't be cured by antibiotic such as methicillin and vancomycin. It was demonstrated that baicalin, an active natural compound extracted from the traditional Chinese medicinal, possess antimicrobial activity. In the present study, we evaluate it efficacy in vitro and vivo against this isolated methicillin-resistant S.aureus (MRSA). Our findings demonstrated that baicalin can inhibit S. aureus growth in a dose-dependent manner and attenuate the biofilm formation. Scanning electron microscopies showed that cell membrane was damaged and accompany with contents leaks after treated with high concentration of baicalin. In addition, baicalin exerted inhibitory effects on the expression of S.aureus virulence-related factors. Moreover, baicalin treated mice had enhanced survival after a lethal dose of S.aureus infection compared with untreated mice. Simultaneously, the pathological tissue damage and bacterium burden were decrease in baicalin treated mice. These data demonstrated that baicalin displayed a high effectiveness in vitro and vivo against MRSA infection, suggesting that baicalin may potentially be used to treat MRSA infection.
机译：金黄色葡萄球菌（S.aureus）从肺炎中遭受的猪分离，不能通过抗生素如甲氧西林和万古霉素治愈。据证明，黄芩苷，一种从中药中提取的活性天然化合物，具有抗微生物活性。在本研究中，我们在体外和体内评估其对该分离的甲氧西林抗性S.aureus（MRSA）的疗效。我们的研究结果表明，黄芩苷可以以剂量依赖性方式抑制金黄色葡萄球菌生长并衰减生物膜形成。扫描电子显微镜显示，在高浓度的黄芩苷处理后，细胞膜损坏并伴随着内容物泄漏。此外，黄芩苷对S.aureus毒力学相关因素的表达施加抑制作用。此外，与未处理的小鼠相比，乳白处理的小鼠在致死剂量的S.aureus感染后的存活率增强。同时，病理组织损伤和细菌负担在黄芩苷处理的小鼠中减少。这些数据表明，黄芩苷对体外和体内对MRSA感染的高效性显示出高效果，这表明BACICAL可能用于治疗MRSA感染。

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