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首页> 外文期刊>Microbial Pathogenesis >Epigenetics evaluation of the oncogenic mechanisms of two closely related bovine and human deltaretroviruses: A system biology study
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Epigenetics evaluation of the oncogenic mechanisms of two closely related bovine and human deltaretroviruses: A system biology study

机译：两个密切相关的牛和人类狭窄病毒的致癌机制的表观遗传学评价：一种系统生物学研究

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Human T-cell lymphotropic virus (HTLV-1) and bovine leukemia virus (BLV) are oncogenic deltaretroviruses, which are the cause of adult T cell leukemia/lymphoma (ATLL) and enzootic bovine leukosis (EBL), respectively. In this study, to evaluate the virus-host interactions in the manifestation of the associated malignancy, four pooled RNA samples of each host (three RNAs in each sample) were applied to RNA-seq. Differential expression analyses were conducted separately between ATLL and EBL groups, in comparison with the healthy group, to identify functional Gene Ontology (GO) terms and hub genes, using DAVID database and MCODE plugin in Cytoscape software, respectively. A broad range of effective genes, involved in the ATLL and EBL, was up- and downregulated. In the virus side, in both malignancy, Tax was expressed very low, but the HTLV-1-HBZ and BVL-As2 transcripts were highly expressed. Some upregulated hub genes, IL2, TOP2A, MKI67, TP73, MYC, and downregulated FOS gene family (FOS, FOSB, and FOSL2), are similarly activated in both human and bovine hosts, in related cell cycle and growth factors. Taken together, it seems that in preventing the infections and cell transformations, Tax must be targeted as a viral factor, and shared peptide in virological and immunological synapses as host factors. Therefore, in the malignant stages, HBZ and As2 transcripts along with growth factors, particularly IL-2R-gamma and T-bet or TOP2A, and MKI67 should be targeted in both hosts. Additional studies at the protein level are necessary to elucidate the more useful targets for the therapy of these life-threatening diseases.
机译：人T细胞淋巴细胞病毒（HTLV-1）和牛白血病病毒（BLV）是一种致癌梗死病毒，它们分别是成人T细胞白血病/淋巴瘤（ATLL）和Enzootic牛白血病（EBL）的原因。在该研究中，为了评估病毒 - 宿主在相关恶性肿瘤的表现中的相互作用中，将每种宿主的四个合并的RNA样品（每个样品中的三个RNA）应用于RNA-SEQ。与健康组相比，在ATLL和EBL基团之间分别进行差异表达分析，以分别使用David数据库和MCODE插件在Cytoscape软件中鉴定功能基因本体（GO）术语和集线器基因。涉及ATLL和EBL的广泛的有效基因，上调和下调。在病毒方面，在恶性肿瘤中，税表达得非常低，但HTLV-1-HBz和BVL-AS2转录物高度表达。一些上调的轮毂基因，IL2，TOP2A，MKI67，TP73，MYC和下调的FOS基因家族（FOS，FOSB和FOSL2）在人和牛宿主中类似地激活相关细胞周期和生长因子。在一起，似乎在预防感染和细胞转化中，税必须靶向病毒因素，并且在病毒学和免疫突触中共享肽作为宿主因子。因此，在恶性阶段，HBZ和AS2转录物以及生长因子，特别是IL-2R-γ和T-BET或TOP2A，以及MKI67应靶向。蛋白质水平的额外研究是阐明对这些生命危及疾病的治疗的更有用的靶标。

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