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Invasiveness of the Yersinia pestis ail protein contributes to host dissemination in pneumonic and oral plague

机译：盐蛋白的侵袭性AIL蛋白有助于在肺炎和口腔瘟疫中宿主

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摘要

Yersinia pestis, a Gram-negative bacterium, is the etiologic agent of plague. A hallmark of Y. pestis infection is the organism's ability to rapidly disseminate through an animal host. Y. pestis expresses the outer membrane protein, Ail (Attachment invasion locus), which is associated with host invasion and serum resistance. However, whether Ail plays a role in host dissemination remains unclear. In this study, C57BL/6J mice were challenged with a defined Y. pestis strain, KimD27, or an isogenic ail-deleted mutant derived from KimD27 via metacarpal paw pad inoculation, nasal drops, orogastric infection, or tail vein injection to mimic bubonic, pneumonic, oral, or septicemic plague, respectively. Our results showed that ail-deleted Y. pestis KimD27 lost the ability to invade host cells, leading to failed host dissemination in the pneumonic and oral plague models but not in the bubonic or septicemic plague models, which do not require invasiveness. Therefore, this study demonstrated that whether Ail plays a role in Y. pestis pathogenesis depends on the infection route.
机译：鉴赏植物，一种革兰氏阴性细菌，是瘟疫的病因试剂。 Y. pestis感染的标志是有机体能够通过动物宿主快速传播。 Y. Pestis表达了外膜蛋白，AIL（附着侵袭轨迹），其与宿主侵袭和血清抗性相关。但是，无论AIL是否在宿主传播中发挥作用仍然不清楚。在本研究中，C57BL / 6J小鼠用定义的Y.Pestis菌株，KiMd27或来自Kimd27的衍生自Metacarpal Paw垫接种，鼻滴，愤怒感染或尾静脉注射到模拟冒泡的毒性菌株，KimD27或Isogenic Ail缺失突变体攻击。肺炎，口服或血迷瘟疫。我们的研究结果表明，Pestis Kimd27失去了侵袭宿主细胞的能力，导致肺炎和口腔瘟疫模型中的宿主传播失败，而不是在不需要侵袭性的吸水性或血迷瘟疫模型中。因此，本研究表明，无菌是否在y中发挥作用.Pestis发病机制取决于感染途径。

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