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首页> 外文期刊>Microbial Pathogenesis >Antibiofilm and anticancer potential of beta-glucan-binding protein-encrusted zinc oxide nanoparticles
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Antibiofilm and anticancer potential of beta-glucan-binding protein-encrusted zinc oxide nanoparticles

机译：β-葡聚糖结合蛋白质覆盖氧化锌纳米粒子的抗血栓和抗癌电位

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摘要

beta-Glucan-binding protein (f3GBP) is important for the rational expansion of molecular biology. Here, zinc oxide nanoparticle (ZnONP) was synthesized using fiGBP from the crab Scylla serrata (Ss-beta GBP-ZnONP). Ss-beta GBPZnONP was observed as a 100 kDa band on sodium dodecyl sulfate polyacrylamide gel and characterized with UV-vis spectroscopy at 350 nm. X-ray diffraction analysis displayed values consistent with those for zincite. Fourier transform infrared spectroscopy revealed the presence of functional groups, including amide, alcohol, alkane, alkyl halide, and alkene groups. The zeta potential ( - 5.36 mV) of these particles indicated their stability, and transmission electron microscopy revealed the presence of 50 nm nanocones. Ss-beta GBP-ZnONPs were tested at 100 mu g/mL against the gram-positive Enterococcus faecalis and gram-negative Pseudomanas aeruginosa using confocal laser scanning microscopy and the bacterial viability assay was also performed. The growth of MCF7 breast cancer cells was inhibited following treatment with 75 mu g/mL Ss-beta GBP-ZnONPs. Thus, Ss-beta GBPZnONPs have the ability to control the growth of pathogenic bacteria and inhibit the viability of MCF7 breast cancer cell lines.
机译：β-葡聚糖结合蛋白（F3GBP）对于分子生物学的合理扩张是重要的。这里，使用Flab Scylla Serrata（SS-Beta GBP-ZnONP）合成氧化锌纳米颗粒（ZnONP）。在十二烷基硫酸钠聚丙烯酰胺凝胶上观察到SS-βGBPZNONP作为100kDa带，并在350nm处用UV-Vis光谱表征。 X射线衍射分析显示与锌岩的值一致。傅里叶变换红外光谱显示出官能团的存在，包括酰胺，醇，烷烃，烷基卤和烯基。这些颗粒的Zeta电位（ - 5.36mV）表明它们的稳定性，透射电子显微镜显示出50nm纳米烷酮的存在。将SS-βGBP-ZnOnps以100μg/ ml测试，抗革兰氏阳性肠球菌粪便，并且使用共聚焦激光扫描显微镜进行克革兰阴性伪铜绿假单节，并且还进行细菌活力测定。用75μg/ ml SS-βGBP-ZnONPS处理后抑制MCF7乳腺癌细胞的生长。因此，SS-βGBPZNONP具有控制致病细菌的生长并抑制MCF7乳腺癌细胞系的活力。

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