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首页> 外文期刊>Micron: The international research and review journal for microscopy >Micro-computed tomography, scanning electron microscopy and energy X-ray spectroscopy studies of facet joint degeneration: A comparison to clinical imaging
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Micro-computed tomography, scanning electron microscopy and energy X-ray spectroscopy studies of facet joint degeneration: A comparison to clinical imaging

机译：微型计算机断层扫描，扫描电子显微镜和刻面关节退化的能量X射线光谱研究：与临床成像进行比较

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摘要

Segmental degeneration in the human lumbar spine affects both the intervertebral discs and facet joints. Facet joint degeneration not only affects the cartilage surface, but also alters the cellular properties of the cartilage tissue and the structure of the subchondral bone. The primary focus of this study is the investigation of these microstructural changes that are caused by facet joint degeneration. Microstructural analyses of degenerated facet joint samples, obtained from patients following operative lumbar interbody fusion, have not previously been extensively investigated. This study analyzes human facet joint samples from the inferior articular process using scanning electron microscopy, micro-computed tomography, and energy dispersive X-ray spectroscopy to evaluate parameters of interest in facet joint degeneration such as elemental composition, cartilage layer thickness and cell density, calcification zone thickness, subchondral bone portion, and trabecular bone porosity. These microstructural analyses demonstrate fragmentation, cracking, and destruction of the cartilage layer, a thickened calcification zone, localized calcification areas, and cell cluster formation as pathological manifestations of facet joint degeneration. The detailed description of these microstructural changes is critical for a comprehensive understanding of the pathology of facet joint degeneration, as well as the subsequent development and efficacy analysis of regenerative treatment strategies.
机译：人腰椎中的节段性退化会影响椎间盘和面部关节。面部关节变性不仅影响软骨表面，而且还改变了软骨组织的细胞性质和子骨髓内骨的结构。本研究的主要焦点是调查由面关节变性引起的这些微观结构变化。从术后腰椎椎间融合术后的患者中获得的重新组织关节样本的微观结构分析尚未得到广泛调查。本研究使用扫描电子显微镜，微计算机断层扫描和能量分散X射线光谱分析人的小关节样品，微观的断层扫描和能量分散X射线光谱，以评估在面部关节变性的关节参数，如元素组成，软骨层厚度和细胞密度，钙化区厚度，骨髓内部部分和小梁骨孔隙率。这些微观结构分析显示了软骨层的碎片，开裂和破坏，增厚的钙化区，局部钙化区域和细胞簇形成，作为小关节变性的病理表现。这些微观结构变化的详细描述对于综合了解小型关节退化的病理以及再生治疗策略的随后发育和功效分析至关重要。

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