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首页> 外文期刊>Microscopy research and technique >Quantitative characterization and diagnosis via hard X-ray phase-contrast microtomography
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Quantitative characterization and diagnosis via hard X-ray phase-contrast microtomography

机译：硬X射线相位对比度微观图的定量表征和诊断

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摘要

Nondestructive three-dimensional (3D) micromorphological imaging technique is essential for hepatic alveolar echinococcosis (HAE) disease to determine its damage level and early diagnosis, assess relative drug therapy and optimize treatment strategies. However, the existing morphological researches of HAE mainly depend on the conventional CT, MRI, or ultrasound in hospitals, unfortunately confronting with the common limit of imaging resolution and sensitivity, especially for tiny or early HAE lesions. Now we presented a phase-retrieval-based synchrotron X-ray phase computed tomography (PR-XPCT) with striking contrast-to-noise ratio and high-density resolution to visualize the HAE nondestructive 3D structures and quantitatively segment different pathological characteristics of HAE lesions without staining process at the micrometer scale. Our experimental results of the HAE rat models at early and developed pathological stages and albendazole liposome (L-ABZ) therapeutic feeding models successfully exhibited the different HAE pathological 3D morphological and microstructural characteristics with excellent contrast and high resolution, demonstrating its availability and superiority. Moreover, we achieved the quantitative statistics and analysis of the pathological changes of HAE lesions at different stages and L-ABZ therapeutic evaluation, helpful to understanding the development and drug treatment of HAE disease. The PR-XPCT-based quantitative segmentation and characterization has a great potential in detection and analysis of soft tissue pathological changes, such as different tumors.
机译：无损三维（3D）微观成像技术对于肝脏肺炎菌（HAE）疾病至关重要，以确定其损伤水平和早期诊断，评估相对药物治疗和优化治疗策略。然而，HAE的现有形态学研究主要取决于传统的CT，MRI或超声波，不幸地面对成像分辨率和敏感性的共同限制，特别是对于微小或早期的HAE病变。现在我们介绍了一种基于阶段检索的同步X射线相位断层扫描（PR-XPCT），具有引人注目的对比度和高密度分辨率，以可视化HAE非破坏性3D结构和定量分段HAE病变的不同病理特征在微米刻度下没有染色过程。我们在早期和发育病理阶段的Hae大鼠模型的实验结果和脂肪唑脂质体（L-ABZ）治疗饲养模型成功地表现出不同的HAE病理3D形态学和微观结构特征，具有出色的对比度和高分辨率，展示其可用性和优越性。此外，我们达到了不同阶段和L-ABZ治疗评价的HAE病变病理变化的定量统计和分析，有助于了解HAE病的发育和药物治疗。基于PR-XPCT的定量分割和表征具有巨大的检测和分析软组织病理变化，例如不同的肿瘤。

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