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首页> 外文期刊>BJU international >The influence of body mass index on the long-term survival of patients with renal cell carcinoma after tumour nephrectomy.
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The influence of body mass index on the long-term survival of patients with renal cell carcinoma after tumour nephrectomy.

机译：体重指数对肿瘤肾切除术后肾细胞癌患者长期生存的影响。

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OBJECTIVE: To assess whether under- or overweight at the time of surgery has any effect on the survival of the patients with renal cell carcinoma (RCC), as obesity increases the risk of developing RCC. PATIENTS AND METHODS: We prospectively evaluated 780 patients who had nephrectomy for RCC between 1990 and 2005. We used uni- and multivariate Cox proportional hazards models to assess the effect of body mass index (BMI), tumour stage, Fuhrman grade, age, sex, histological type and performance status on cancer-specific survival (CSS). Patients were grouped according to BMI (in kg/m(2)), as underweight (<18.5), normal (18.5-<25), overweight (25-<30) and obese (>or=30). RESULTS: The median (range) follow-up was 5.3 (0.5-15.4) years, the patients being followed until June 2006; 254 patients died during the follow-up. Multivariate analyses of all patients showed that tumour stage, Fuhrman grade, Karnofsky performance status, age, sex and BMI were independent prognostic factors for CSS. While underweight patients had a significantly worse prognosis than those of normal weight, overweight or obese patients had a similar outcome to that of patients of normal weight. In a subgroup analyses including patients with localized RCC only, there was a strong tendency to less aggressive disease in the overweight group (P = 0.081). CONCLUSIONS: Being underweight is an unfavourable and new risk factor for CSS in patients with RCC treated by nephrectomy. Although not significant, there seems to be a limited favourable prognostic effect of overweight on CSS in patients with localized RCC.
机译：目的：评估手术时体重过轻或超重对肾细胞癌（RCC）患者的生存是否有影响，因为肥胖会增加患RCC的风险。患者与方法：我们对1990年至2005年间780例接受RCC肾切除术的患者进行了前瞻性评估。我们使用单变量和多变量Cox比例风险模型评估了体重指数（BMI），肿瘤分期，福尔曼分级，年龄，性别的影响，关于癌症特异性生存（CSS）的组织学类型和表现状态。根据体重指数（kg / m（2））将患者分为体重不足（<18.5），正常（18.5- <25），超重（25- <30）和肥胖（> or = 30）。结果：中位（范围）随访时间为5.3（0.5-15.4）年，患者随访至2006年6月。 254名患者在随访期间死亡。所有患者的多因素分析表明，肿瘤分期，Fuhrman分级，Karnofsky行为状态，年龄，性别和BMI是CSS的独立预后因素。体重过轻的患者的预后显着低于正常体重的患者，而超重或肥胖的患者的预后与正常体重的患者相似。在仅包括局部RCC患者的亚组分析中，超重组有强烈的减少侵略性疾病的趋势（P = 0.081）。结论：体重不足是肾切除术治疗的RCC患者CSS的不利和新的危险因素。尽管不重要，但对于局限性RCC患者，超重对CSS的有利预后似乎有限。

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