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首页> 外文期刊>Crystal Research and Technology: Journal of Experimental and Industrial Crystallography >Isolation, characterization and phase transformation of new ginsenoside compound k hydrate and methanol solvates
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Isolation, characterization and phase transformation of new ginsenoside compound k hydrate and methanol solvates

机译：新人参皂苷化合物k水合物和甲醇溶剂化物的分离，表征和相变

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摘要

Two new solvates of ginsenoside compound K (nonstoichiometric hydrate/CKH and methanol solvate/CKM) have been discovered and characterized in this paper. They were obtained through cooling crystallization in different solvents, and CKM could be prepared by transformation from CKH as well. The solvates were analysed by Power X-ray diffraction (PXRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and fourier transform infrared (FTIR) spectroscopy. From the thermal studies, it is shown that the two new products are both solvates with different onset melting points. The PXRD and FTIR data support different crystal structures of them. It also describes the solution-mediated phase transformation from CKH to CKM with a combination usage of process analytical technology tools. It is shown that the transformation process can be divided into three stages. The results reveal that seeding and low temperature help to accelerate the transformation, but initial solution concentration do little to the transformation kinetics. The kinetics and the rate-controlling step for the transformation depend on the nucleation of the CKM.
机译：本文发现了两种新的人参皂苷K溶剂化物（非化学计量水合物/ CKH和甲醇溶剂化物/ CKM）。它们是通过在不同溶剂中冷却结晶而获得的，CKM也可以通过从CKH转化而制得。通过功率X射线衍射（PXRD），差示扫描量热法（DSC），热重分析（TGA）和傅立叶变换红外光谱（FTIR）光谱分析溶剂化物。从热学研究表明，这两种新产品都是具有不同起始熔点的溶剂化物。 PXRD和FTIR数据支持它们的不同晶体结构。它还描述了解决方案介导的从CKH到CKM的相变，以及过程分析技术工具的组合使用。结果表明，转换过程可以分为三个阶段。结果表明，晶种和低温有助于加速转化，但初始溶液浓度对转化动力学影响很小。转化的动力学和速率控制步骤取决于CKM的成核。

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