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Understanding relaxin signalling at the cellular level

机译：了解蜂窝水平的松弛素信令

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摘要

The peptide hormone relaxin mediates many biological actions including anti-fibrotic, vasodilatory, angiogenic, anti-inflammatory, anti-apoptotic, and organ protective effects across a range of tissues. At the cellular level, relaxin binds to the G protein-coupled receptor relaxin family peptide receptor 1 (RXFP1) to activate a variety of downstream signal transduction pathways. This signalling cascade is complex and also varies in diverse cellular backgrounds. Moreover, RXFP1 signalling shows crosstalk with other receptors to mediate some of its physiological functions. This review summarises known signalling pathways induced by acute versus chronic treatment with relaxin across a range of cell types, it describes RXFP1 crosstalk with other receptors, signalling pathways activated by other ligands targeting RXFP1, and it also outlines physiological relevance of RXFP1 signalling outputs. Comprehensive understanding of the mechanism of relaxin actions in fibrosis, vasodilation, as well as organ protection, will further support relaxin's clinical potential.
机译：肽激素松弛素介导许多生物学作用，包括抗纤维化，血管舒张，血管生成，抗炎，抗凋亡，抗凋亡，抗凋亡，抗凋亡和器官保护作用，以及各种组织。在细胞水平，松弛素与G蛋白偶联受体松弛素家族肽受体1（RXFP1）结合，以激活各种下游信号转导途径。该信号级联是复杂的，并且在不同的蜂窝背景中也有所不同。此外，RXFP1信号传导显示串扰与其他受体介导其一些生理功能。本综述总结了急性急性慢性治疗诱导的已知信令途径，在一系列细胞类型中，用弛豫素与其他受体描述RxFP1串扰，由靶向RxFP1的其他配体激活的信号传导途径，并且还概述了RXFP1信号传导输出的生理相关性。综合了解纤维化，血管血管和器官保护的松弛素作用机制将进一步支持松弛素的临床潜力。

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