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首页> 外文期刊>Molecular and Cellular Endocrinology >Effect of SULT2B1 genetic polymorphisms on the sulfation of dehydroepiandrosterone and pregnenolone by SULT2B1b allozymes
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Effect of SULT2B1 genetic polymorphisms on the sulfation of dehydroepiandrosterone and pregnenolone by SULT2B1b allozymes

机译：Sult2b1遗传多态性对苏尔2B1B同联酶脱氢贫康松和妊娠苯酚的影响

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摘要

Pregnenolone and dehydroepiandrosterone (DHEA) are hydroxysteroids that serve as biosynthetic precursors for steroid hormones in human body. SULT2B1b has been reported to be critically involved in the sulfation of pregnenolone and DHEA, particularly in the sex steroid-responsive tissues. The current study was designed to investigate the impact of the genetic polymorphisms of SULT2B1 on the sulfation of DHEA and pregnenolone by SULT2B1b allozymes. Ten SULT2B1b allozymes previously prepared were shown to exhibit differential sulfating activities toward DHEA and pregnenolone in comparison to the wild-type enzyme. Kinetic studies revealed further significant changes in their substrate-binding affinity and catalytic activity toward DHEA and pregnenolone. Taken together, these results indicated clearly a profound effect of SULT2B1 genetic polymorphisms on the sulfating activity of SULT2B1b allozymes toward DHEA and pregnenolone, which may have implications in inter-individual variations in the homeostasis of these two important steroid precursors.
机译：孕蛋白和脱氢哌啶（DHEA）是患者曲目，作为人体类固醇激素的生物合成前体。据报道，SULT2B1B旨在批判性地参与孕蛋白和DHEA的硫化，特别是在性类固醇响应组织中。目前的研究旨在探讨SULT2B1遗传多态性对DHEA和孕苯酚的硫化遗传多态性的影响。与野生型酶相比，示出了先前制备的10个先前制备的苏尔2B1B同联酶对DHEA和妊娠酚醛化合物表现出差异硫酸化活性。动力学研究表明，其基质结合亲和力和催化活性对DHEA和妊娠蛋白的进一步显着变化。总之，这些结果表明SULT2B1遗传多态性对DHEA和妊娠毒剂硫化活性的深刻作用，这可能对这两个重要的类固醇前体的稳态间的各种变化可能具有影响。

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