• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Molecular biology reports >Ruthenium pyridyl thiocyanate complex increased the production of pro-inflammatory TNF alpha and IL1 beta cytokines by the LPS stimulated mammalian macrophages in vitro
【24h】

Ruthenium pyridyl thiocyanate complex increased the production of pro-inflammatory TNF alpha and IL1 beta cytokines by the LPS stimulated mammalian macrophages in vitro

机译：硫氰酸钌酸钌络合物通过LPS在体外刺激哺乳动物巨噬细胞的促炎TNFα和IL1β细胞因子的产生增加

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Every cell in our body depends on the electron transport processes in order to generate energy and function properly. Being able to regulate the metabolic activity of a cell would enable us altering its function and eventually lead us to a desired biological outcome at the cellular level and more desirably at a systemic level. Immunomodulatory or immunostimulatory molecules have been focus of the recent studies in order to regulate or boost the activities of the immune system cells and suppress or eliminate the disease conditions such as cancer, autoimmune reactions, inflammatory disorders as well as infections. In our study we used a ruthenium pyridyl thiocyanate complex, K330, to examine its effect on the activity of the innate immune system cells, macrophages in vitro. K330 was our candidate due to its application in the solar cells. Especially, due to its ability to get involved in electron transfer systems we hypothesized that it could change the activity of the immune system cells at cellular level, possibly by interfering the electron transfer reactions of the cells. Our results support our hypothesis since K330 lead to a significant increase in TNF alpha and IL1 beta cytokine production levels by LPS stimulated macrophages compared to only LPS treated control groups. Based on our in vitro results, K330 can also be utilized as an adjuvant candidate in vaccinations where the antigen itself is not sufficient to generate a proper immune response.
机译：我们身体中的每个细胞都依赖于电子传输过程，以便能够正确地产生能量和功能。能够调节细胞的代谢活性将使我们能够改变其功能，并最终通过在细胞水平的期望的生物结果中，更理想地在全身水平上。免疫调节或免疫刺激分子的重点是最近的研究，以调节或促进免疫系统细胞的活性并抑制或消除癌症，自身免疫反应，炎症性疾病以及感染等疾病病症。在我们的研究中，我们使用了甲酰吡啶鎓硫氰酸氢盐络合物K330，以检查其对在体外巨噬细胞的先天免疫系统细胞的活性的影响。 K330是我们的候选人，因为它在太阳能电池中的应用。特别是，由于其能够参与电子转移系统，我们假设它可以通过干扰细胞的电子转移反应来改变细胞水平的免疫系统细胞的活性。我们的结果支持我们的假设，因为K330导致TNFα和IL1β细胞因子产生水平的显着增加，而LPS刺激的巨噬细胞与仅LPS处理的对照组相比。基于我们的体外结果，K330也可以用作抗原本身不足以产生适当的免疫应答的疫苗疫苗中的佐剂候选者。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号