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首页> 外文期刊>Addiction >Smoking reduction promotes smoking cessation: results from a double blind, randomized, placebo-controlled trial of nicotine gum with 2-year follow-up.
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Smoking reduction promotes smoking cessation: results from a double blind, randomized, placebo-controlled trial of nicotine gum with 2-year follow-up.

机译：减少吸烟可促进戒烟：一项对尼古丁胶进行的双盲，随机，安慰剂对照试验，随访期2年。

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AIM: To test the effect of nicotine gum and placebo in smokers not motivated or not able to quit smoking with regard to smoking reduction and smoking cessation. DESIGN: This randomized study evaluated nicotine gum versus placebo for up to 1 year in 411 healthy smokers highly motivated to reduce cigarette use. Smoking reduction was defined as self-reported daily smoking less than 50% of baseline and any decrease (1 p.p.m. or more) in carbon monoxide. SETTING: Pulmonary department, Copenhagen, Denmark. FINDINGS: The overall success rate for sustained smoking reduction was significantly higher at all time-points for active versus placebo gum (6.3% versus 0.5% after 24 months). Nicotine gum achieved significantly higher point prevalence cessation rates than placebo at 12 and 24 months [11.2% versus 3.9% (odds ratio = 3.1; 95% CI, 1.4-7.2 and 9.3% versus 3.4% (odds ratio = 2.9; 95% CI, 1.2-7.1), respectively]. There was a linear relationship between decrease in number of daily cigarettes and decrease in plasma cotinine, exhaled carbon monoxide and plasma thiocyanate, with significantly greater reduction in the nicotine gum group after 4 and 12 months (maximum treatment duration) but not after 24 months. The decrease in toxin intake was smaller than the decline in daily cigarette consumption, suggesting that compensatory smoking occurred. CONCLUSIONS: Nicotine gum promoted cessation in this population of smokers unwilling to quit. Among reducers, the toxin intake correlated with reduced cigarette consumption although some compensatory smoking occurred.
机译：目的：在减少吸烟和戒烟方面，测试尼古丁口香糖和安慰剂对无动力或不能戒烟的吸烟者的影响。设计：这项随机研究在411名积极减少吸烟的健康吸烟者中评估了尼古丁口香糖与安慰剂的对比，长达1年。减少吸烟的定义为自我报告的每日吸烟少于基线的50％，以及一氧化碳的任何减少（每天下午1点或更多）。地点：丹麦哥本哈根，肺科。研究结果发现，在所有时间点上，主动吸烟者与安慰剂者相比，持续吸烟的总体成功率要高得多（24个月后分别为6.3％和0.5％）。尼古丁口香糖在12和24个月时的戒烟率显着高于安慰剂[11.2％比3.9％（优势比= 3.1; 95％CI，1.4-7.2和9.3％比3.4％（优势比= 2.9; 95％CI） （分别为1.2-7.1）]。每天卷烟数量的减少与血浆可替宁，呼出气一氧化碳和血浆硫氰酸盐的减少之间存在线性关系，尼古丁口香糖组在4和12个月后的减少显着更大（最大治疗持续时间），但未在24个月后。毒素摄入量的减少小于每日吸烟量的减少，这表明发生了代偿性吸烟。结论：尼古丁胶促进了不愿戒烟的烟民戒烟。尽管发生了一些补偿性吸烟，但摄入量与减少香烟消费量相关。

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