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首页> 外文期刊>Mucosal immunology >CCR2(-) andCCR2(+) corneal macrophages exhibit distinct characteristics and balance inflammatory responses after epithelial abrasion
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CCR2(-) andCCR2(+) corneal macrophages exhibit distinct characteristics and balance inflammatory responses after epithelial abrasion

机译：CCR2（ - ）和CCR2（+）角膜巨噬细胞表现出明显的特征和上皮磨损后的炎症反应

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摘要

Macrophages are distributed throughout the body and are crucial for the restoration of damaged tissues. However, their characteristics in the cornea and roles in the repair of corneal injures are unclear. Here we show that corneal macrophages can be classified asCCR2(-) macrophages, which already exist in the cornea at embryonic day 12.5 (E12.5) and are similar to yolk sac-derived macrophages, microglia, in phenotype and gene expression, and CCR2(+) macrophages, which do not appear in the cornea until E17.5. At a steady state, CCR2(-) corneal macrophages have local proliferation capacity and are rarely affected by monocytes; however, following corneal epithelial abrasion, mostCCR2(-) corneal macrophages are replaced by monocytes. In contrast, CCR2(-) macrophages are repopulated by monocytes under both a steady- state condition and following corneal wounding. Depletion of CCR2(+) macrophages decreases corneal inflammation after epithelial abrasion, whereas depletion ofCCR2(-) macrophages increases inflammation of the injured cornea. Loss of either cell type results in a delay in corneal healing. These data indicate that there are two unique macrophage populations present in the cornea, both of which participate in corneal wound healing by balancing the inflammatory response.
机译：巨噬细胞分布在整个身体上，对恢复受损组织至关重要。然而，它们在角膜损伤修复中的角膜和角色的特征尚不清楚。在这里，我们表明角膜巨噬细胞可以分类为Asccr2（ - ）巨噬细胞，该巨噬细胞已经存在于胚胎第12.5天（E12.5）的角膜中，并且与yolk囊型巨噬细胞，小胶质细胞，表型和基因表达类似，以及CCR2 （+）巨噬细胞，不会出现在角膜中直到E17.5。在稳定状态下，CCR2（ - ）角膜巨噬细胞具有局部增殖能力，很少受单核细胞的影响;然而，在角膜上皮磨损之后，MOSTCCR2（ - ）角膜巨噬细胞被单核细胞所取代。相比之下，CCR2（ - ）巨噬细胞在稳态条件下并在角膜伤害之后被单核细胞重新灌注。 CCR2（+）巨噬细胞的耗竭降低了上皮磨损后的角膜炎症，而CCR2（ - ）巨噬细胞的耗尽增加了受伤角膜的炎症。一种细胞类型的丧失导致角膜愈合的延迟。这些数据表明角膜中存在两种独特的巨噬细胞群，两者都通过平衡炎症反应参与角膜伤口愈合。

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  • 来源
    《Mucosal immunology》 |2017年第5期|共15页
  • 作者

    Liu J.; Xue Y.; Dong D.; Xiao C.; Lin C.; Wang H.; Song F.; Fu T.; Wang Z.; Chen J.; Pan H.; Li Y.; Cai D.; Li Z.;

  • 作者单位

    Jinan Univ Integrated Chinese &

    Western Med Postdoctoral Res Guangzhou Guangdong Peoples R China;

    Jinan Univ Med Sch Int Ocular Surface Res Ctr Guangzhou Guangdong Peoples R China;

    Jinan Univ Med Sch Int Ocular Surface Res Ctr Guangzhou Guangdong Peoples R China;

    Jinan Univ Minist Educ Key Lab Regenerat Med Guangzhou Guangdong Peoples R China;

    Jinan Univ Med Sch Int Ocular Surface Res Ctr Guangzhou Guangdong Peoples R China;

    Jinan Univ Minist Educ Key Lab Regenerat Med Guangzhou Guangdong Peoples R China;

    Jinan Univ Minist Educ Key Lab Regenerat Med Guangzhou Guangdong Peoples R China;

    Jinan Univ Med Sch Int Ocular Surface Res Ctr Guangzhou Guangdong Peoples R China;

    Third Peoples Hosp Dept Med Images Puyang Peoples R China;

    Jinan Univ Med Sch Int Ocular Surface Res Ctr Guangzhou Guangdong Peoples R China;

    Jinan Univ Med Sch Int Ocular Surface Res Ctr Guangzhou Guangdong Peoples R China;

    Jinan Univ Minist Educ Key Lab Regenerat Med Guangzhou Guangdong Peoples R China;

    Jinan Univ Minist Educ Key Lab Regenerat Med Guangzhou Guangdong Peoples R China;

    Jinan Univ Med Sch Int Ocular Surface Res Ctr Guangzhou Guangdong Peoples R China;

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  • 正文语种 eng
  • 中图分类 基础医学;
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