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首页> 外文期刊>Addiction biology >Serum levels of vascular endothelial growth factor A increase during alcohol withdrawal.
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Serum levels of vascular endothelial growth factor A increase during alcohol withdrawal.

机译:戒酒期间血清血管内皮生长因子A水平升高。

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Vascular endothelial growth factor A (VEGF-A) is a key regulator of angiogenesis. This study investigated VEGF-A serum levels during alcohol withdrawal (days 1, 7 and 14, 76 male patients, 38 healthy controls). Patients showed significantly higher VEGF-A serum levels (t = 2.620, P = 0.010), which increased significantly during withdrawal (F = 4.484, P = 0.014, mean difference = -36.835, P = 0.037). The increase of VEGF-A serum levels was significantly associated with initial breath alcohol concentration and the sumscore of the severity scale of alcohol dependence (SESA questionnaire, F = 5.252, P = 0.008). Increase of VEGF-A serum levels is closely associated to alcohol intoxication and severity of alcohol dependence.
机译:血管内皮生长因子A(VEGF-A)是血管生成的关键调节剂。这项研究调查了戒酒期间(第1、7和14天,76例男性患者,38例健康对照者)的VEGF-A血清水平。患者显示出明显更高的VEGF-A血清水平(t = 2.620,P = 0.010),在停药期间显着增加(F = 4.484,P = 0.014,平均差异= -36.835,P = 0.037)。 VEGF-A血清水平的增加与初始呼吸酒精浓度和酒精依赖严重程度评分的总分显着相关(SESA调查表,F = 5.252,P = 0.008)。 VEGF-A血清水平的升高与酒精中毒和酒精依赖的严重程度密切相关。

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