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首页> 外文期刊>Addiction biology >Brain activation patterns associated with cue reactivity and craving in abstinent problem gamblers, heavy smokers and healthy controls: an fMRI study.
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Brain activation patterns associated with cue reactivity and craving in abstinent problem gamblers, heavy smokers and healthy controls: an fMRI study.

机译：一项功能磁共振成像研究，与禁欲赌徒，重度吸烟者和健康对照者的提示反应性和渴望相关的大脑激活模式。

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摘要

Abnormal cue reactivity is a central characteristic of addiction, associated with increased activity in motivation, attention and memory related brain circuits. In this neuroimaging study, cue reactivity in problem gamblers (PRG) was compared with cue reactivity in heavy smokers (HSM) and healthy controls (HC). A functional magnetic resonance imaging event-related cue reactivity paradigm, consisting of gambling, smoking-related and neutral pictures, was employed in 17 treatment-seeking non-smoking PRG, 18 non-gambling HSM, and 17 non-gambling and non-smoking HC. Watching gambling pictures (relative to neutral pictures) was associated with higher brain activation in occipitotemporal areas, posterior cingulate cortex, parahippocampal gyrus and amygdala in PRG compared with HC and HSM. Subjective craving in PRG correlated positively with brain activation in left ventrolateral prefrontal cortex and left insula. When comparing the HSM group with the two other groups, no significant differences in brain activity induced by smoking cues were found. In a stratified analysis, the HSM subgroup with higher Fagerstrom Test for Nicotine Dependence scores (FTND M = 5.4) showed higher brain activation in ventromedial prefrontal cortex, rostral anterior cingulate cortex, insula and middle/superior temporal gyrus while watching smoking-related pictures (relative to neutral pictures) than the HSM subgroup with lower FTND scores (FTND M = 2.9) and than non-smoking HC. Nicotine craving correlated with activation in left prefrontal and left amygdala when viewing smoking-related pictures in HSM. Increased regional responsiveness to gambling pictures in brain regions linked to motivation and visual processing is present in PRG, similar to neural mechanisms underlying cue reactivity in substance dependence. Increased brain activation in related fronto-limbic brain areas was present in HSM with higher FTND scores compared with HSM with lower FTND scores.
机译：提示反应性异常是成瘾的主要特征，与动机，注意力和记忆相关的脑回路活动增加有关。在这项神经影像研究中，将问题赌徒（PRG）中的提示反应性与重度吸烟者（HSM）和健康对照（HC）中的提示反应性进行了比较。功能性磁共振成像事件相关的提示反应性范式，包括与赌博，吸烟相关和中性的图片，被用于17位寻求治疗的非吸烟PRG，18位非赌博的HSM和17位非赌博和非吸烟的患者HC。与HC和HSM相比，观看赌博图片（相对于中性图片）与PRG中枕颞区，后扣带回皮层，海马旁回和杏仁核的大脑激活更高有关。 PRG的主观渴望与左腹外侧前额叶皮层和左岛的大脑激活呈正相关。将HSM组与其他两组进行比较时，未发现吸烟提示引起的大脑活动有显着差异。在分层分析中，对烟碱依赖性分数较高的Fagerstrom测验（FTND M = 5.4）的HSM亚组显示腹侧前额叶皮层，前额扣带回皮层，岛状和中/上颞回中较高的大脑激活，同时观看与吸烟相关的图片（相对于中性图片），HSND分组的FTND得分较低（FTND M = 2.9），并且比不吸烟的HC高。在HSM中查看与吸烟相关的图片时，尼古丁的渴望与左前额叶和左杏仁核的激活相关。 PRG中出现了与动机和视觉处理相关的大脑区域对赌博图片的区域反应性增强，类似于物质依赖中提示反应的神经机制。与FTND分数较低的HSM相比，FTND分数较高的HSM中存在相关的前额叶大脑区域的大脑激活增加。

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