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首页> 外文期刊>Addiction biology >Neuropeptide Y system in accumbens shell mediates ethanol self-administration in posterior ventral tegmental area
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Neuropeptide Y system in accumbens shell mediates ethanol self-administration in posterior ventral tegmental area

机译：伏伏核壳中的神经肽Y系统介导后腹侧被盖区的乙醇自我管理

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Although modulatory effects of neuropeptide Y (NPY) on ethanol consumption are well established, its role in ethanol reward, in the framework of mesolimbic dopaminergic system, has not been studied. We investigated the influence of nucleus accumbens shell (AcbSh) NPYergic system on ethanol self-administration in posterior ventral tegmental area (p-VTA) using intracranial self-administration paradigm. Rats were stereotaxically implanted with cannulae targeted unilaterally at the right p-VTA and trained to self-administer ethanol (200mg%) in standard two-lever (active/inactive) operant chamber, an animal model with high predictive validity to test the rewarding mechanisms. Over a period of 7 days, these rats showed a significant increase in the number of lever presses for ethanol self-administration suggesting reinforcement. While intra-AcbSh NPY (1 or 2ng/rat) or [Leu(31), Pro(34)]-NPY (0.5 or 1ng/rat) dose-dependently increased ethanol self-administration, BIBP3226 (0.4 or 0.8ng/rat) produced opposite effect. The rats conditioned to self-administer ethanol showed significant increase in the population of NPY-immunoreactive cells and fibres in the AcbSh, central nucleus of amygdala (CeA), hypothalamic arcuate nucleus (ARC) and lateral part of bed nucleus of stria terminalis as compared with that in the naive rats. Neuronal tracing studies showed that NPY innervations in the AcbSh may derive from the neurons of ARC and CeA. As NPY and dopamine systems in reward areas are known to interact, we suggest that NPY inputs from ARC and CeA may play an important role in modulation of the dopaminergic system in the AcbSh and consequently influence the ethanol induced reward and addiction.
机译：尽管已经很好地确定了神经肽Y（NPY）对乙醇消耗的调节作用，但尚未研究其在中脑边缘多巴胺能系统框架内对乙醇奖励的作用。我们调查了伏隔核壳（AcbSh）NPYergic系统对后腹侧被盖区（p-VTA）中乙醇自我给药的影响，采用颅内自我给药范例。大鼠被立体定向​​植入单侧靶向正确的p-VTA的插管，并经过训练可以在标准的两杆（活动/非活动）手术室中自我给药乙醇（200mg％），该动物模型具有较高的预测有效性，可以测试奖励机制。在7天的时间里，这些大鼠的酒精自用杠杆按压次数显着增加，表明需要加强。尽管AcbSh内NPY（1或2ng /大鼠）或[Leu（31），Pro（34）]-NPY（0.5或1ng /大鼠）剂量依赖性地增加了乙醇的自我管理，BIBP3226（0.4或0.8ng /大鼠） ）产生相反的效果。自我适应乙醇的大鼠显示，AcbSh，杏仁核中枢核（CeA），下丘脑弓状核（ARC）和床状纹状体床核外侧部分的NPY免疫反应性细胞和纤维数量显着增加。在幼稚的老鼠身上。神经元追踪研究表明，AcbSh中的NPY神经支配可能源自ARC和CeA的神经元。由于已知奖励区域中的NPY和多巴胺系统会相互作用，因此我们建议来自ARC和CeA的NPY输入可能在AcbSh中多巴胺能系统的调节中起重要作用，从而影响乙醇诱导的奖励和成瘾。

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