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首页> 外文期刊>Addiction biology >Residual performance impairments in adult rats trained on an object discrimination task subsequent to cocaine administration during adolescence.
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Residual performance impairments in adult rats trained on an object discrimination task subsequent to cocaine administration during adolescence.

机译：在青春期服用可卡因后接受对象识别任务训练的成年大鼠的残余性能受损。

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The present study was conducted to determine whether cognitive impairments in adult rats treated with cocaine during adolescence demonstrated in previous investigations extend to tests of object discrimination learning. Accordingly, 30-day-old male Long-Evans rats were injected subcutaneously with either 10 or 20 mg/kg cocaine or received control injections of saline for 7-8 consecutive days. An extended abstinence period was then introduced (mean = 70.7 +/- 9.8 days) before subjects, who were now young adults (mean = 106.3 +/- 10.2 days old), were assessed for acquisition of a two-choice object discrimination task. Using a correctional learning procedure conducted in a water maze, subjects were trained (eight trials per day for 10 days) to approach one of two multi-dimentional 'junk' objects. Although all animals acquired the discrimination to a reasonable extent, cocaine-treated subjects exhibited lower percentages of correct choices over the course of training (10 mg/kg = 59.6 +/- 7.2% and 20 mg/kg = 59.4 +/- 4.9%) relative to the saline control group (67.5 +/- 4.9%). Further analyses revealed that saline-treated subjects acquired proficient discrimination performance earlier during the course of training, achieving an approximate 72% performance rate after only 3 days of training. This was in contrast to the two cocaine-treated groups needing 7 days of training to achieve comparable levels of performance. In addition, saline-treated subjects required significantly fewer trials (20.8 +/- 8.9) than either cocaine-treated group (10 mg/kg = 52.2 +/- 11.9 and 20 mg/kg = 63.3 +/- 8.7) to reach an 87.5% correct response criterion (i.e. 7-correct-out-of-8-consecutive-trials) and performed at a higher above-chance level (13.5%) than either cocaine-treated group (3.6% and 5.3% for the 10 and 20 mg/kg cocaine groups, respectively). These findings demonstrate the existence of cognitive impairments in adulthood subsequent to cocaine exposure during adolescence despite a prolonged drug-free interval. Speculation regarding the neurobiological basis for this effect, especially with regard to alterations to prefrontal circuitry, is provided.
机译：进行本研究以确定先前研究中证实的青春期可卡因治疗成年大鼠的认知障碍是否扩展到对象歧视学习测试。因此，给30日龄的雄性Long-Evans大鼠皮下注射10或20 mg / kg可卡因，或连续7-8天接受对照盐水注射。然后引入延长的禁欲期（平均= 70.7 +/- 9.8天），然后评估现在是年轻成年人（平均= 106.3 +/- 10.2天）的受试者完成两项选择对象识别任务。使用在水迷宫中进行的矫正学习程序，对受试者进行了训练（每天进行8次试验，共10天），以接近两个多维“垃圾”物体之一。尽管所有动物都在一定程度上获得了歧视，但可卡因治疗的受试者在训练过程中的正确选择百分比较低（10 mg / kg = 59.6 +/- 7.2％和20 mg / kg = 59.4 +/- 4.9％ ）相对于生理盐水对照组（67.5 +/- 4.9％）。进一步的分析表明，用盐水治疗的受试者在训练过程中较早地获得了出色的辨别力，仅训练了3天就达到了约72％的表现率。这与两个可卡因治疗组需要7天的培训才能达到可比较的性能水平形成鲜明对比。此外，与任一可卡因治疗组（10 mg / kg = 52.2 +/- 11.9和20 mg / kg = 63.3 +/- 8.7）相比，盐水治疗的受试者所需的试验次数（20.8 +/- 8.9）要少得多。正确反应标准为87.5％（即，连续8次试验中有7次正确），并且比可卡因治疗组的成功率（13.5％）高（13.5％）（10和10％分别为3.6％和5.3％）分别为20 mg / kg可卡因组）。这些发现表明，尽管延长了无毒品间隔时间，但在青春期暴露于可卡因后成人中存在认知障碍。提供了关于这种作用的神经生物学基础的推测，尤其是关于额叶前额叶回路改变的推测。

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