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首页> 外文期刊>Addiction biology >Sex-dependent effects of maternal deprivation and adolescent cannabinoid treatment on adult rat behaviour.
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Sex-dependent effects of maternal deprivation and adolescent cannabinoid treatment on adult rat behaviour.

机译：母体剥夺和青少年大麻素治疗对成年大鼠行为的性别依赖性影响。

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摘要

Early life experiences such as maternal deprivation (MD) exert long-lasting changes in adult behaviour and reactivity to stressors. Adolescent exposure to cannabinoids is a predisposing factor in developing certain psychiatric disorders. Therefore, the combination of the two factors could exacerbate the negative consequences of each factor when evaluated at adulthood. The objective of this study was to investigate the long-term effects of early MD [24 hours at postnatal day (PND) 9] and/or an adolescent chronic treatment with the cannabinoid agonist CP-55,940 (0.4 mg/kg, PND 28-42) on diverse behavioural and physiological responses of adult male and female Wistar rats. We tested them in the prepulse inhibition (PPI) of the startle response and analysed their exploratory activity (holeboard) and anxiety (elevated plus maze, EPM). In addition, we evaluated their adrenocortical reactivity in response to stress and plasma leptin levels. Maternal behaviour was measured before and after deprivation. MD induced a transient increase of maternal behaviour on reuniting. In adulthood, maternally deprived males showed anxiolytic-like behaviour (or increased risk-taking behaviour) in the EPM. Adolescent exposure to the cannabinoid agonist induced an impairment of the PPI in females and increased adrenocortical responsiveness to the PPI test in males. Both, MD and adolescent cannabinoid exposure also induced sex-dependent changes in plasma leptin levels and body weights. The present results indicate that early MD and adolescent cannabinoid exposure exerted distinct sex-dependent long-term behavioural and physiological modifications that could predispose to the development of certain neuropsychiatric disorders, though no synergistic effects were found.
机译：诸如孕产妇剥夺（MD）的早期生活经历使成年人的行为和对压力源的反应性产生了持久的变化。青少年接触大麻素是发展某些精神疾病的诱因。因此，在成年期评估时，两个因素的组合可能会加剧每个因素的负面影响。这项研究的目的是研究早期MD的长期作用[产后第24天（PND）9]和/或大麻素激动剂CP-55,940（0.4 mg / kg，PND 28- 42）关于成年雄性和雌性Wistar大鼠的各种行为和生理反应。我们在惊吓反应的脉冲前抑制（PPI）中对其进行了测试，并分析了其探索性活动（钻孔）和焦虑症（高强度迷宫，EPM）。此外，我们评估了它们对应激和血浆瘦素水平的响应。在剥夺之前和之后测量孕产妇的行为。 MD会导致母亲团聚时的行为暂时增加。成年后，被剥夺孕产的男性在EPM中表现出类似抗焦虑的行为（或冒险行为增加）。青少年接触大麻素激动剂会导致女性PPI受损，男性对PPI测试的肾上腺皮质反应性增加。 MD和青少年大麻素暴露也都引起血浆瘦素水平和体重的性别依赖性变化。目前的结果表明，虽然没有发现协同作用，但早期的MD和青少年大麻素暴露具有明显的性别依赖性长期行为和生理变化，这些行为可能导致某些神经精神疾病的发展。

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