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首页> 外文期刊>Addiction biology >Prairie voles as a novel model of socially facilitated excessive drinking.
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Prairie voles as a novel model of socially facilitated excessive drinking.

机译：草原田鼠是社会上促进过度饮酒的新模式。

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Social relationships strongly affect alcohol drinking in humans. Traditional laboratory rodents do not exhibit social affiliations with specific peers, and cannot adequately model how such relationships impact drinking. The prairie vole is a socially monogamous rodent used to study social bonds. The present study tested the prairie vole as a potential model for the effects of social affiliations on alcohol drinking. Same-sex adult sibling prairie voles were paired for five days, and then either separated into individual cages, or housed in pairs. Starting at the time of separation, the voles received unlimited access to alcohol in a two-bottle choice test versus water. Pair-housed siblings exhibited higher preference for alcohol, but not saccharin, than singly housed voles. There was a significant correlation between the amount of alcohol consumed by each member of a pair when they were housed together (r = 0.79), but not when housed apart (r = 0.20). Following automated analysis of circadian patterns of fluid consumption indicating peak fluid intake before and after the dark phase, a limited access two-hour two-bottle choice procedure was established. Drinking in this procedure resulted in physiologically relevant blood ethanol concentrations and increased Fos immunoreactivity in perioculomotor urocortin containing neurons (but not in nucleus accumbens or central nucleus of the amygdala). The high ethanol preference and sensitivity to social manipulation indicate that prairie voles can serve to model social influences on excessive drinking.
机译：社会关系强烈影响人类饮酒。传统的实验室啮齿动物没有表现出与特定同伴的社交关系，也无法充分模拟这种关系如何影响饮酒。草原田鼠是用于研究社会纽带的一夫一妻制的啮齿动物。本研究测试了草原田鼠作为社会隶属关系对饮酒影响的潜在模型。将同性成年兄弟姐妹大田鼠配对五天，然后分成单独的笼子，或成对安置。从分离之时开始，在两瓶选择测试中，与水相比，田鼠无限制地获得了酒精。与单独饲养的田鼠相比，成对饲养的兄弟姐妹对酒精的偏好更高，但对糖精的偏好更高。当一对夫妇的每个成员在一起时，所消耗的酒精量之间存在显着相关性（r = 0.79），但分开放置时则没有（r = 0.20）。在对耗油量的昼夜节律模式进行了自动分析后，表明在黑暗阶段之前和之后都出现了峰值采食量，建立了有限的两小时两瓶选择程序。在此过程中饮酒会导致生理上相关的血液乙醇浓度升高，并且在包含运动性尿皮质激素的神经元（但在伏隔核或杏仁核中枢却没有）中增加Fos免疫反应性。乙醇的高度偏爱和对社交操纵的敏感性表明，草原田鼠可以用来模拟社交对过量饮酒的影响。

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