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首页> 外文期刊>Addiction biology >Brain reactivity to emotional, neutral and cigarette-related stimuli in smokers.
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Brain reactivity to emotional, neutral and cigarette-related stimuli in smokers.

机译：吸烟者的大脑对情绪，中性和香烟相关刺激的反应性。

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摘要

Addiction has been described as the pathological usurpation of the neural mechanisms normally involved in emotional processing. Event-related potentials (ERPs) can provide a non-invasive index of neural responses associated with the processing of emotionally relevant stimuli and serve as a tool for examining temporal and spatial commonalities between the processing of intrinsically motivating stimuli and drug cues. Before beginning a smoking cessation program, 116 smokers participated in a laboratory session in which dense-array ERPs (129 sensors) were recorded during the presentation of pictures with emotional (pleasant and unpleasant), neutral and cigarette-related content. ERP differences among categories were analyzed with use of randomization tests on time regions of interest identified by temporal principal component analysis. Both emotional and cigarette-related pictures prompted significantly more positivity than did neutral pictures over central, parietal, and frontal sites in the 452-508 ms time window. During the 212-316 ms time window, both pleasant and cigarette-related pictures prompted less positivity than neutral images did. Cigarette-related pictures enhanced the amplitude of the P1 component (136-144 ms) above the levels measured in the emotional and neutral conditions. These results support the hypothesis that for smokers, cigarette-related cues are motivationally relevant stimuli that capture attentional resources early during visual processing and engage brain circuits normally involved in the processing of intrinsically emotional stimuli.
机译：成瘾已被描述为通常参与情绪加工的神经机制的病理篡改。事件相关电位（ERP）可以提供与情感相关刺激的处理相关的神经反应的非侵入性指标，并且可以用作检查内在激励刺激和药物提示之间的时间和空间共性的工具。在开始戒烟计划之前，有116位吸烟者参加了一次实验室会议，在演示过程中记录了情感（愉快和不愉快），中性和香烟相关内容的密集阵列ERP（129个传感器）。使用随机测试对通过时间主成分分析确定的感兴趣的时间区域分析类别之间的ERP差异。在452-508毫秒的时间范围内，情绪图片和与香烟相关的图片都比在中部，顶叶和额叶部位的中性图片显示出更多的阳性。在212-316毫秒的时间范围内，与中性图像相比，令人愉悦的图像和与香烟相关的图像都显示出较低的积极性。与香烟相关的图片将P1成分的振幅（136-144毫秒）提高到了在情绪和中性条件下测得的水平。这些结果支持以下假设：对于吸烟者，与香烟相关的提示是与动机相关的刺激，可以在视觉处理过程中尽早捕获注意力资源，并使通常参与内在情绪刺激处理的大脑回路参与其中。

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